| 题名 | BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 |
| 作者 | Samelson, Avi J.1,2; Tran, Quang Dinh3,4; Robinot, Remy5; Carrau, Lucia6; Rezelj, Veronica V.3; Mac Kain, Alice3,4; Chen, Merissa1,2; Ramadoss, Gokul N.7,8; Guo, Xiaoyan1,2; Lim, Shion A.9,19; Lui, Irene9; Nunez, James K.10,11; Rockwood, Sarah J.7; Wang, Jianhui12  ; Liu, Na12; Carlson-Stevermer, Jared13; Oki, Jennifer13; Maures, Travis13; Holden, Kevin13; Weissman, Jonathan S.10,11,14,15; Wells, James A.2,9,10; Conklin, Bruce R.7,10,16,17; TenOever, Benjamin R.6; Chakrabarti, Lisa A.5; Vignuzzi, Marco3; Tian, Ruilin1,2,13 ; Kampmann, Martin1,2,18
|
| 通讯作者 | Tian, Ruilin; Kampmann, Martin |
| 发表日期 | 2022
|
| DOI | |
| 发表期刊 | |
| ISSN | 1465-7392
|
| EISSN | 1476-4679
|
| 卷号 | 24期号:1页码:24-34 |
| 摘要 | ["Samelson et al. report that BRD2 inhibition suppresses SARS-CoV-2 infection in epithelial cells and Syrian hamsters via reducing the transcription of host cell surface receptor ACE2.","SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. Here we show that the protein BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clinical trials potently block endogenous ACE2 expression and SARS-CoV-2 infection of human cells, including those of human nasal epithelia. Moreover, pharmacological BRD2 inhibition with the drug ABBV-744 inhibited SARS-CoV-2 replication in Syrian hamsters. We also found that BRD2 controls transcription of several other genes induced upon SARS-CoV-2 infection, including the interferon response, which in turn regulates the antiviral response. Together, our results pinpoint BRD2 as a potent and essential regulator of the host response to SARS-CoV-2 infection and highlight the potential of BRD2 as a therapeutic target for COVID-19."] |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 通讯
|
| 资助项目 | NIH[F32AG063487]
|
| WOS研究方向 | Cell Biology
|
| WOS类目 | Cell Biology
|
| WOS记录号 | WOS:000742323100001
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：48
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/272407 |
| 专题 | 南方科技大学医学院 南方科技大学医学院_医学神经科学系 |
| 作者单位 | 1.Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94118 USA 2.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA 3.Inst Pasteur, Viral Populat & Pathogenesis Unit, Paris, France 4.Univ Paris, Ecole Doctorale BioSPC, Sorbonne Paris Cite, Paris, France 5.Univ Paris, Inst Pasteur, Virus & Immun Unit, CIVIC Grp, Paris, France 6.NYU Langone, Dept Microbiol, New York, NY USA 7.Gladstone Inst, San Francisco, CA USA 8.Univ Calif San Francisco, Biomed Sci PhD Program, San Francisco, CA USA 9.Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA 10.Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA USA 11.Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA USA 12.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 13.Synthego Corp, Redwood City, CA 94063 USA 14.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA 15.MIT, Dept Biol, Cambridge, MA USA 16.Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA 17.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA 18.Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA 19.Genentech Inc, Dept Antibody Engn, 460 Point San Bruno Blvd, San Francisco, CA 94080 USA |
| 推荐引用方式 GB/T 7714 |
Samelson, Avi J.,Tran, Quang Dinh,Robinot, Remy,et al. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2[J]. NATURE CELL BIOLOGY,2022,24(1):24-34.
|
| APA |
Samelson, Avi J..,Tran, Quang Dinh.,Robinot, Remy.,Carrau, Lucia.,Rezelj, Veronica V..,...&Kampmann, Martin.(2022).BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.NATURE CELL BIOLOGY,24(1),24-34.
|
| MLA |
Samelson, Avi J.,et al."BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2".NATURE CELL BIOLOGY 24.1(2022):24-34.
|
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| 10.1038@s41556-021-0（5015KB） | -- | -- | 开放获取 | -- | 浏览 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论