The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease

Shen, Shengnan1,2,3; Liao, Qiwen4; Wong, Yin Kwan5; Chen, Xiao6; Yang, Chuanbin7,8; Xu, Chengchao1,2; Sun, Jichao7,8,9; Wang, Jigang1,2,10,11,12

2022

10.7150/ijbs.66871

International Journal of Biological Sciences   影响因子和分区

1449-2288

In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal protein processing, oxidative stress and proinflammatory cytokines will drive the activation of inflammatory pathways, leading to low-grade chronic inflammation and insulin resistance (IR) in the periphery and impaired neuronal insulin signaling in the brain. Studies have shown that such inflammation and impaired insulin signaling contribute to the development of Alzheimer's disease (AD). Therefore, new therapeutic strategies are needed for the treatment of T2DM and T2DM-linked AD. Melatonin is primarily known for its circadian role which conveys message of darkness and induces night-state physiological functions. Besides rhythm-related effects, melatonin has anti-inflammatory and antioxidant properties. Melatonin levels are downregulated in metabolic disorders with IR, and activation of melatonin signaling delays disease progression. The aim of this Review is to highlight the therapeutic potentials of melatonin in preventing the acceleration of AD in T2DM individuals through its therapeutic mechanisms, including antioxidative effects, anti-inflammatory effects, restoring mitochondrial function and insulin sensitivity.

Melatonin Type 2 diabetes Alzheimer's disease Mitochondria Anti-inflammatory Insulin resistance

SCI

英语

通讯

National Key Research and Development Program of China["2020YFA0908000","2020YFE0205100"] ; National Natural Science Foundation of China[81903588,81803456,81702580,82074098,81841001,81903866,81803389,82104183] ; CACMS Innovation Fund[CI2021A05101] ; Fundamental Research Funds for the Central public welfare research institutes["ZZ13-ZD-07","ZZ14-YQ-050","ZZ14-YQ-051","ZZ14-YQ-056","ZZ14-ND-010","ZZ15-ND-10"] ; Macau Young Scholars Program[AM2020027] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002]

Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics

Biochemistry & Molecular Biology ; Biology

WOS:000741664100007

IVYSPRING INT PUBL

Web of Science

1.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
3.Univ Macau, Inst Chinese Medcal Sci, State Key Lab Qual Res Chinese Med, Taipa, Madhya Pradesh, Peoples R China
4.Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen, Guangdong, Peoples R China
5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore
6.China Pharmaceut Univ, Sch Biopharm, Nanjing 211198, Peoples R China
7.Jinan Univ, Dept Geriatr, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Peoples R China
8.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
9.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Shenzhen, Peoples R China
10.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou, Peoples R China
11.Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrov, Minist Educ, Ganzhou, Peoples R China
12.Cent Peoples Hosp Zhanjiang, Zhanjiang, Guangdong, Peoples R China

Shen, Shengnan,Liao, Qiwen,Wong, Yin Kwan,et al. The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease[J]. International Journal of Biological Sciences,2022,18(3).

Shen, Shengnan.,Liao, Qiwen.,Wong, Yin Kwan.,Chen, Xiao.,Yang, Chuanbin.,...&Wang, Jigang.(2022).The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.International Journal of Biological Sciences,18(3).

Shen, Shengnan,et al."The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease".International Journal of Biological Sciences 18.3(2022).