南方科技大学知识苑(SUSTech KC): Atom-Economical and Stereoselective Difunctionalization of Electron-Withdrawing Alkynes with N-Trifluoromethylthiophthalimide

题名	Atom-Economical and Stereoselective Difunctionalization of Electron-Withdrawing Alkynes with N-Trifluoromethylthiophthalimide
作者	Li, Juncheng 1; Yang, Zhiping 1; Guo, Rui 1; Jin, Ming Yu1,2 ; Wang, Jun (Joelle)1
通讯作者	Jin, Ming Yu; Wang, Jun (Joelle)
发表日期	2018-09
DOI	10.1002/ajoc.201800351
发表期刊	Asian Journal of Organic Chemistry 影响因子和分区
ISSN	2193-5807
EISSN	2193-5815
卷号	7 期号:9页码:1784-1787
摘要	An N-methylmorpholine-catalyzed aminotrifluoromethylthiolation of electron-withdrawing alkynes leads to ,alpha,beta-unsaturated esters bearing a nitrogen and SCF3 groups. Here, N-trifluoromethylthiophthalimide serves as both the nitrogen and the SCF3 source. This difunctionalization reaction features mild reaction conditions, high atom economy, good yield (up to 93%) and excellent stereoselectivity (Z/E up to 28:1). This study provides a versatile approach for the synthesis of -SCF3-containing molecules (i.e. alpha,beta-SCF3-beta-amino acids).
关键词	difunctionalization atom-economy E/Z selectivity trifluoromethylthiolation alkynes
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Basic Research Program[JCYJ20170817110005371] ; Shenzhen Basic Research Program[JCYJ20170412152435366]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000444409700006
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：9
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/27262
专题	理学院_化学系前沿与交叉科学研究院
作者单位	1.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Guangdong, Peoples R China
第一作者单位	化学系
通讯作者单位	化学系; 前沿与交叉科学研究院
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Li, Juncheng,Yang, Zhiping,Guo, Rui,et al. Atom-Economical and Stereoselective Difunctionalization of Electron-Withdrawing Alkynes with N-Trifluoromethylthiophthalimide[J]. Asian Journal of Organic Chemistry,2018,7(9):1784-1787.
APA	Li, Juncheng,Yang, Zhiping,Guo, Rui,Jin, Ming Yu,&Wang, Jun .(2018).Atom-Economical and Stereoselective Difunctionalization of Electron-Withdrawing Alkynes with N-Trifluoromethylthiophthalimide.Asian Journal of Organic Chemistry,7(9),1784-1787.
MLA	Li, Juncheng,et al."Atom-Economical and Stereoselective Difunctionalization of Electron-Withdrawing Alkynes with N-Trifluoromethylthiophthalimide".Asian Journal of Organic Chemistry 7.9(2018):1784-1787.