Cu(ii)-Catalyzed C2-site functionalization of p-aminophenols: an approach for selective cross-dehydrogenative aminations

Zhao, Xin1,2,3; Yang, Fang1,2; Wang, Lin-Lin1,2; Guo, Jing1,2; Xu, Yu-Qin1,2; Chen, Zi-Sheng1,2; Ji, Kegong1,2,4

2021-12-01

10.1039/d1qo01675j

Organic Chemistry Frontiers   影响因子和分区

2052-4129

Site selective cross dehydrogenative aminations from precursors without preactivated C-H and N-H bonds have been challenging. Herein, a copper-catalyzed C2-site selective amination of p-aminophenol derivatives with arylamines has been developed. This approach precludes both partners from prefunctionalization and yields single site selective aminated products. This reaction proceeds smoothly with air as a terminal oxidant to produce the corresponding C2-site functional aminophenol derivatives in moderate to good yields.

SCI ; EI

英语

通讯

National Natural Science Foundation of China["NSF-21702170",22171228] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]

Chemistry

Chemistry, Organic

WOS:000741521500001

ROYAL SOC CHEMISTRY

20220811703852

Amines ; Copper compounds

Chemical Reactions:802.2 ; Organic Compounds:804.1

Web of Science

1.Northwest A&F Univ, Coll Chem & Pharm, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China
2.Shaanxi Key Lab Nat Prod & Chem Biol, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China
3.Baotou Med Coll, Sch Pharm, Baotou 014060, Inner Mongolia, Peoples R China
4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

Zhao, Xin,Yang, Fang,Wang, Lin-Lin,et al. Cu(ii)-Catalyzed C2-site functionalization of p-aminophenols: an approach for selective cross-dehydrogenative aminations[J]. Organic Chemistry Frontiers,2021,9:1010-1015.

Zhao, Xin.,Yang, Fang.,Wang, Lin-Lin.,Guo, Jing.,Xu, Yu-Qin.,...&Ji, Kegong.(2021).Cu(ii)-Catalyzed C2-site functionalization of p-aminophenols: an approach for selective cross-dehydrogenative aminations.Organic Chemistry Frontiers,9,1010-1015.

Zhao, Xin,et al."Cu(ii)-Catalyzed C2-site functionalization of p-aminophenols: an approach for selective cross-dehydrogenative aminations".Organic Chemistry Frontiers 9(2021):1010-1015.