The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species

Yang, Fang1,2; Sun, Yi3; Lu, Qiaoyun4

2022-01-12

10.1186/s12866-021-02433-6

BMC MICROBIOLOGY   影响因子和分区

1471-2180

Background This study was aimed to determine the potency of Minocycline (MIN) and azoles, including itraconazole (ITR), voriconazole (VOR) and posaconazole (POS) against Scedosporium and Lomentospora species. Results This study revealed that MIN exhibited no significant antifungal activity against any of the tested strains, whereas in vitro combination of MIN with ITR, VOR or POS showed satisfactory synergistic effects against 8 (80%), 1 (10%), and 9 (90%) strains, respectively. Moreover, combined use of MIN with azoles decreased the minimum inhibitory concentration (MIC) range from 5.33-16 mu g/ml to 1-16 mu g/ml for ITR, from 0.42-16 mu g/ml to 0.21-16 mu g/ml for VOR, and from 1.33-16 mu g/ml to 0.33-16 mu g/ml for POS. Meanwhile, no antagonistic interactions were observed between the above combinations. The G. mellonella infection model demonstrated the in vivo synergistic antifungal effect of MIN and azoles. Conclusions The present study demonstrated that combinations between MIN and azoles lead to synergistic antimicrobial effects on Scedosporium and Lomentospora species, while showing a potential for overcoming and preventing azole resistance.

Scedosporium Lomentospora Minocycline Azole Synergy Antifungal effect Resistance

SCI

英语

第一

Health Commission of Hubei Province scientific research project[WJ2021M261] ; Natural Science Foundation of Hubei Province[2019CFB567]

Microbiology

Microbiology

WOS:000741366600001

BMC

MICROBIOLOGY

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1,Dept Dermatol, Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen, Peoples R China
3.Yangtze Univ, Jingzhou Cent Hosp, Clin Med Coll 2, Dept Dermatol, Jingzhou, Hubei, Peoples R China
4.Hubei Univ Arts & Sci, Xiangyang Cent Hosp, Affiliated Hosp, Xiangyang, Hubei, Peoples R China

Yang, Fang,Sun, Yi,Lu, Qiaoyun. The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species[J]. BMC MICROBIOLOGY,2022,22(1).

Yang, Fang,Sun, Yi,&Lu, Qiaoyun.(2022).The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species.BMC MICROBIOLOGY,22(1).

Yang, Fang,et al."The synergistic effect of minocycline and azole antifungal drugs against Scedosporium and Lomentospora species".BMC MICROBIOLOGY 22.1(2022).