Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study

Jiang, Wei1; Li, Fu-Rong2,3; Yang, Huan-Huan4; Chen, Guo-Chong5,6; Hua, Yong-Fei1

2021-12-31

10.3389/fnut.2021.771984

Frontiers in Nutrition   影响因子和分区

2296-861X

Background: N-3 long-chain polyunsaturated fatty acids (LCPUFAs) prevented non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in studies of mouse models. We examined prospective relationships between fish oil use and risk of primary liver cancer and the major histological subtypes, such as HCC and intrahepatic cholangiocarcinoma (ICC).Methods: We included 434,584 middle-aged and older men and women who were free of cancer at recruitment of the UK Biobank (2006-2010). Information on fish oil use and other dietary habits was collected via questionnaires. Cox proportional hazards models were used to compute the hazard ratio (HR) and 95% CI of liver cancer associated with fish oil use, with adjustment for socio-demographic, lifestyle, dietary, and other clinical risk factors.Results: At baseline, 31.4% of participants reported regular use of fish oil supplements. During a median of 7.8 years of follow-up, 262 incident liver cancer cases were identified, among which 127 were HCC and 110 were ICC cases. As compared with non-users, fish oil users had a significantly 44% (95% CI: 25-59%) lower risk of total liver cancer, and 52% (95% CI: 24-70%) and 40% (95% CI: 7-61%) lower risk of HCC and ICC, respectively. Higher intake of oily fish also was associated with a lower risk of HCC (>= 2 vs. P-trend = 0.027) but not ICC (P-trend = 0.96).Conclusion: Habitual use of fish oil supplements was associated lower risk of primary liver cancer regardless of cancer histological subtypes, potentially supporting a beneficial role of dietary n-3 LCPUFAs in liver cancer prevention.

fish fish oil hepatocellular carcinoma liver cancer polyunsaturated fatty acids

SCI

英语

其他

Nutrition & Dietetics

Nutrition & Dietetics

WOS:000745667900001

FRONTIERS MEDIA SA

Web of Science

1.Ningbo Univ, Ningbo Med Ctr, Dept Hepatopancreatobiliary Surg, Lihuili Hosp, Ningbo, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Southern Med Univ, Sch Publ Hlth, Dept Epidmiol, Guangzhou, Peoples R China
4.Tsinghua Univ, Wanke Sch Publ Hlth, Beijing, Peoples R China
5.Albert Einstein Coll Med, Dept Epidmiol & Populat Hlth, Bronx, NY 10467 USA
6.Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China

Jiang, Wei,Li, Fu-Rong,Yang, Huan-Huan,et al. Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study[J]. Frontiers in Nutrition,2021,8.

Jiang, Wei,Li, Fu-Rong,Yang, Huan-Huan,Chen, Guo-Chong,&Hua, Yong-Fei.(2021).Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study.Frontiers in Nutrition,8.

Jiang, Wei,et al."Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study".Frontiers in Nutrition 8(2021).