Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones

Luo, Shihui1; Meng, Ling1; Yang, Qingxiong2; Wang, Jun (Joelle)1

2018-09

10.1055/s-0037-1610225

SYNLETT   影响因子和分区

0936-5214

1437-2096

The enantioselective incorporation of alkyl groups in thiochromones was realized for the first time by a Cu/(R,S)-PPF-(PBu2)-Bu-t-catalyzed conjugate addition of Grignard reagents to thiochromones. With this method, a series of 2-methylthiochromanones were obtained in good yields (up to 96% yield) with moderate-to-good ee values (up to 87% ee). The established method expedites the synthesis of a large library of chiral thiochromanones for further synthetic applications and biological studies.

asymmetric synthesis Grignard reagents conjugate addition thiochromanones flavonoids

SCI ; IC ; CCR

英语

第一 ; 通讯

Chemistry

Chemistry, Organic

WOS:000444457900025

GEORG THIEME VERLAG KG

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
2.Guizhou Normal Univ, Sch Karst Sci, State Engn Technol Inst Karst Desertificat Contro, Guiyang 550001, Guizhou, Peoples R China

Luo, Shihui,Meng, Ling,Yang, Qingxiong,et al. Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones[J]. SYNLETT,2018,29(15):2071-2075.

Luo, Shihui,Meng, Ling,Yang, Qingxiong,&Wang, Jun .(2018).Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones.SYNLETT,29(15),2071-2075.

Luo, Shihui,et al."Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones".SYNLETT 29.15(2018):2071-2075.