B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation

Lin, Fang1,2,3; Jiang, Yan3; Li, Jian1,2; Yan, Tingting3; Fan, Liumin1,2; Liang, Jiansheng3; Chen, Z. Jeffrey4; Xu, Dongqing4; Deng, Xing Wang1,2,3

2018-09

10.1105/tpc.18.00226

PLANT CELL   影响因子和分区

1040-4651

1532-298X

Plants have evolved a delicate molecular system to fine-tune their growth and development in response to dynamically changing light environments. In this study, we found that BBX28, a B-box domain protein, negatively regulates photomorphogenic development in a dose-dependent manner in Arabidopsis thaliana. BBX28 interferes with the binding of transcription factor HY5 to the promoters of its target genes through physical interactions, thereby repressing its activity and negatively affecting HY5-regulated gene expression. In darkness, BBX28 associates with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and undergoes COP1-mediated degradation via the 26S proteasome system. Collectively, these results demonstrate that BBX28 acts as a key factor in the COP1-HY5 regulatory hub by maintaining proper HY5 activity to ensure normal photomorphogenic development in plants.

SCI

英语

NI期刊

通讯

NIH[GM-47850] ; NIH[GM-109076]

Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology

Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology

WOS:000446563700008

AMER SOC PLANT BIOLOGISTS

PLANT & ANIMAL SCIENCE

Web of Science

1.Peking Univ, Sch Adv Agr Sci, Peking Tsinghua Ctr Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
2.Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China
3.Southern Univ Sci & Technol, Dept Biol, Inst Plant & Food Sci, Shenzhen 518055, Peoples R China
4.Univ Texas Austin, Inst Cellular & Mol Biol, Dept Mol Biosci, Ctr Computat Biol & Bioinformat, Austin, TX 78712 USA

Lin, Fang,Jiang, Yan,Li, Jian,et al. B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation[J]. PLANT CELL,2018,30(9):2006-2019.

Lin, Fang.,Jiang, Yan.,Li, Jian.,Yan, Tingting.,Fan, Liumin.,...&Deng, Xing Wang.(2018).B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation.PLANT CELL,30(9),2006-2019.

Lin, Fang,et al."B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation".PLANT CELL 30.9(2018):2006-2019.