Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size

Huang, Yihui1; Guo, Liang1; Chen, Jiwei2; Wu, Meng3; Zhang, Chao4; Liu, Zeming5; Li, Jinpeng2; Li, Kun6; Xiong, Zhongwei7; Wu, Qian7; Li, Zhengwei7; Luo, Kuan8; Yuan, Weiwei9; Wu, Xiaohui7

2022-01-04

10.3389/fmed.2021.671667

FRONTIERS IN MEDICINE   影响因子和分区

2296-858X

Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19.Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients.Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death.Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.

COVID-19 lactate dehydrogenase (LDH) SARS-CoV-2 prognostic factor Leishenshan Hospital

SCI

英语

通讯

General & Internal Medicine

Medicine, General & Internal

WOS:000745696300001

FRONTIERS MEDIA SA

Web of Science

1.Wuhan Univ, Dept Plast Surg, Zhongnan Hosp, Wuhan, Peoples R China
2.Wuhan Univ, Dept Thyroid & Breast Surg, Zhongnan Hosp, Wuhan, Peoples R China
3.Wuhan Univ, Dept Ultrasound, Zhongnan Hosp, Wuhan, Peoples R China
4.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan, Peoples R China
6.Wuhan Univ, Dept Hepatobiliary & Pancreat Surg, Zhongnan Hosp, Wuhan, Peoples R China
7.Wuhan Univ, Dept Neurosurg, Zhongnan Hosp, Wuhan, Peoples R China
8.Wuhan Puren Hosp, Dept Neurosurg, Wuhan, Peoples R China
9.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Plast & Cosmet Surg,Clin Med Coll 2,Jinan Un, Shenzhen, Peoples R China

Huang, Yihui,Guo, Liang,Chen, Jiwei,et al. Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size[J]. FRONTIERS IN MEDICINE,2022,8.

Huang, Yihui.,Guo, Liang.,Chen, Jiwei.,Wu, Meng.,Zhang, Chao.,...&Wu, Xiaohui.(2022).Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size.FRONTIERS IN MEDICINE,8.

Huang, Yihui,et al."Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size".FRONTIERS IN MEDICINE 8(2022).