南方科技大学知识苑(SUSTech KC): Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections

题名	Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections
作者	Zhu, Qing 1; Chen, Shuyan 2; Gu, Li 3; Qu, Jiuxin 1
通讯作者	Qu, Jiuxin
发表日期	2021
DOI	10.1099/jmm.0.001445
发表期刊	JOURNAL OF MEDICAL MICROBIOLOGY 影响因子和分区
ISSN	0022-2615
EISSN	1473-5644
卷号	70 期号:12
摘要	["Introduction. Human adenovirus (HAdV) is an important pathogen in acute respiratory tract infections (ARTIs) and HAdV genotypes are associated with disease severity.","Hypothesis. Comparative analyses of clinical features could reveal the severity of different HAdV genotypes in ARTIs.","Aim. This study aimed to investigate the molecular epidemiology of HAdV infections and explore the correlations between clinical features and HAdV genotypes.","Methodology. A retrospective study was conducted on ARTIs at Beijing Chao-Yang Hospital during the period 2011-2016. A standardized data form was used to record the clinical information. HAdV was detected by FQ-PCR from respiratory specimens, and genotypes were determined by entire hexon gene sequencing.","Results. A total of 8044 samples were collected, of which 296 (3.7%) were HAdV-positive. Patients <= 44 years old were more likely to be positive for HAdV. There were three peak periods of adenoviral infections, with detection rates of 13.03, 9.39 and 10.38%, respectively. Six HAdV genotypes (HAdV-55, -7, -3, -14, -50, -2) were identified, with HAdV-55 and HAdV-7 being the most prevalent (50.6 and 21.5%). Compared with HAdV-7 and other types, patients infected with HAdV-55 had a longer duration of fever (P=0.0428). Infections with HAdV-55 and HAdV-7 were more severe compared to those caused by other types, with higher rates of oxygen therapy and mechanical ventilation (P=0.0172 and P=0.0144). All five deaths were caused by HAdV-55.","Conclusion. This study describes the epidemiological characteristics of HAdV infections in North China, revealing the higher severity of HAdV-55 and HAdV-7 in ARTIs. Thus, strengthened surveillance of HAdV genotypes is warranted."]
关键词	human adenovirus molecular epidemiology clinical features genotypes HAdV-55 HAdV-7
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Guangdong Basic and Applied Basic Research Foundation[2020A1515010586] ; Science and Technology programme of Shenzhen[JCYJ20190809144005609] ; Shenzhen Key Laboratory of Biochip[ZDSYS201504301534057] ; Special Support Fund of Shenzhen for Introduced High-Level Medical Team[SZSM201412005]
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000743579400010
出版者	MICROBIOLOGY SOC
ESI学科分类	MICROBIOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/273356
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Shenzhen Peoples Hosp 3, Dept Clin Lab, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Shenzhen Peoples Hosp 3, Shenzhen, Peoples R China 3.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhu, Qing,Chen, Shuyan,Gu, Li,et al. Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections[J]. JOURNAL OF MEDICAL MICROBIOLOGY,2021,70(12).
APA	Zhu, Qing,Chen, Shuyan,Gu, Li,&Qu, Jiuxin.(2021).Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections.JOURNAL OF MEDICAL MICROBIOLOGY,70(12).
MLA	Zhu, Qing,et al."Comparative analyses of clinical features reveal the severity of human adenovirus type 55 and type 7 in acute respiratory tract infections".JOURNAL OF MEDICAL MICROBIOLOGY 70.12(2021).