南方科技大学知识苑(SUSTech KC): Alternative translation initiation from two in-frame start codons in DHX33 gene

题名	Alternative translation initiation from two in-frame start codons in DHX33 gene
作者	Wang, Jiuling1,2 ; Yuan, Zhen 2; Zhang, Yandong1
通讯作者	Zhang, Yandong
发表日期	2018-08-25
DOI	10.1016/j.bbrc.2018.05.201
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
ISSN	0006-291X
EISSN	1090-2104
卷号	502 期号:4页码:501-507
摘要	DHX33 has been shown to play key roles in promoting cell proliferation. We have previously found that DHX33 protein is a doublet. In this report, we discovered that DHX33 doublet is due to alternative translation initiation by two in-frame initiation codons. This is supported by studies from both cell lines and mouse models. DHX33 translation initiation from either AUG codon happens at equal efficiency. Short DHX33 protein has similar cellular location and functions with full-length DHX33. Our results suggest that leaky scanning normally occur in DHX33 mRNA translation, which may serve as a safeguard mechanism to ensure optimal DHX33 translation efficiency. This is the first report of DEAD/DEAH box proteins that can be regulated by alternative translation initiation. (C) 2018 Elsevier Inc. All rights reserved.
关键词	DHX33 RNA helicase Leaky scanning Alternative translation
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Department of Science and Technology in Guangdong[2017A020211024]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000437555300011
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ESI学科分类	BIOLOGY & BIOCHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/27340
专题	生命科学学院_生物系
作者单位	1.Southern Univ Sci & Technol, Dept Biol, 1088 Xueyuan Blvd, Shenzhen, Guangdong, Peoples R China 2.Univ Macau, Fac Hlth Sci, Bioimaging Core, Macau, Peoples R China
第一作者单位	生物系
通讯作者单位	生物系
第一作者的第一单位	生物系
推荐引用方式 GB/T 7714	Wang, Jiuling,Yuan, Zhen,Zhang, Yandong. Alternative translation initiation from two in-frame start codons in DHX33 gene[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,502(4):501-507.
APA	Wang, Jiuling,Yuan, Zhen,&Zhang, Yandong.(2018).Alternative translation initiation from two in-frame start codons in DHX33 gene.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,502(4),501-507.
MLA	Wang, Jiuling,et al."Alternative translation initiation from two in-frame start codons in DHX33 gene".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 502.4(2018):501-507.