南方科技大学知识苑(SUSTech KC): Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect

题名	Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect
作者	Bin, Yu-Ling 2; Hu, Hong-Sai 3; Tian, Feng 2; Wen, Zhen-Hua 2; Yang, Mei-Feng 4; Wu, Ben-Hua 1; Wang, Li-Sheng1 ; Yao, Jun 1; Li, De-Feng 1
通讯作者	Li, De-Feng
发表日期	2022-01-12
DOI	10.3389/fonc.2021.745209
发表期刊	Frontiers in Oncology 影响因子和分区
ISSN	2234-943X
卷号	11
摘要	Worldwide, gastric cancer (GC) represents the fifth most common cancer for incidence and the third leading cause of death in developed countries. Despite the development of combination chemotherapies, the survival rates of GC patients remain unsatisfactory. The reprogramming of energy metabolism is a hallmark of cancer, especially increased dependence on aerobic glycolysis. In the present review, we summarized current evidence on how metabolic reprogramming in GC targets the tumor microenvironment, modulates metabolic networks and overcomes drug resistance. Preclinical and clinical studies on the combination of metabolic reprogramming targeted agents and conventional chemotherapeutics or molecularly targeted treatments [including vascular endothelial growth factor receptor (VEGFR) and HER2] and the value of biomarkers are examined. This deeper understanding of the molecular mechanisms underlying successful pharmacological combinations is crucial in finding the best-personalized treatment regimens for cancer patients.
关键词	gastric cancer glycolysis metabolic reprogramming tumor microenvironment drug resistance
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Natural Science Foundation of Guangdong Province[2018A0303100024] ; Three Engineering Training Funds in Shenzhen["SYLY201718","SYJY201714","SYLY201801"] ; Technical Research and Development Project of Shenzhen["JCYJ20210324113802006","JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113"] ; National Natural Science Foundation of China[81800489] ; Natural Science Foundation of Hunan Province[2021JJ70076]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000747930400001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：20
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/273483
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Dept Gastroenterol,Shenzhen Peopl, Shenzhen, Peoples R China 2.ZhuZhou Cent Hosp, Dept Rheumatol & Immunol, Zhuzhou, Peoples R China 3.ZhuZhou Cent Hosp, Dept Gastroenterol, Zhuzhou, Peoples R China 4.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Bin, Yu-Ling,Hu, Hong-Sai,Tian, Feng,et al. Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect[J]. Frontiers in Oncology,2022,11.
APA	Bin, Yu-Ling.,Hu, Hong-Sai.,Tian, Feng.,Wen, Zhen-Hua.,Yang, Mei-Feng.,...&Li, De-Feng.(2022).Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect.Frontiers in Oncology,11.
MLA	Bin, Yu-Ling,et al."Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect".Frontiers in Oncology 11(2022).