p Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging

Gao, Duyang1; Li, Yaxi2; Wu, Yayun1; Liu, Yu1; Hu, Dehong1; Liang, Simin3; Liao, Jiuling1; Pan, Min3; Zhang, Pengfei1; Li, Kai2; Liu, Xin1; Zheng, Hairong1; Sheng, Zonghai1

2022

10.1021/acsami.1c22700

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

The application of an exogenous polymer matrix to construct aggregation-induced emission (AIE) nanoprobes promotes the utility of AIE luminogens (AIEgens) in diagnosing brain diseases. However, the limited fluorescence (FL) and low active-targeting abilities of AIE-based nanoprobes impede their imaging application. Here, we employed endogenous albumin as an effective matrix to encapsulate AIEgens to enhance FL quantum yield (QY) and activetargeting ability. The albumin-consolidated strategy effectively inhibited the intramolecular vibration of AIEgens and enhanced endocytosis mediated by the gp60 receptor. The QYs of three kinds of albumin-based AIE nanoprobes with FL emissions ranging from the visible (400-650 nm) to the second near-infrared (NIR-II, 1000- 1700 nm) region was at least 10% higher, and the tumor-targeting efficiency was similar to 25% higher, compared with those of nanoprobes constructed by the exogenous polymer. Albumin-based AIE nanoprobes have achieved active-targeting NIR-II imaging of brain tumors and cerebrovascular imaging with a high signal-to-background ratio (SBR, similar to 90) and high resolution (similar to 70 mu m) in mouse models. Therefore, the albumin-based AIE nanoprobes will enable FL imaging-guided surgery of brain tumors and cerebral ischemia, which will improve surgical efficacy to prevent recurrence and side effects.

fluorescence imaging second near-infrared window AIE nanoprobes brain diseases albumin

SCI ; EI

英语

其他

Natural Science Foundation of China[82171958,81771906,91859117,81901812,81971638,82027803,81927807,92159304] ; CAS Key Laboratory of Health Informatics[2011DP173015] ; Science and Technology Key Project of Shenzhen["JCYJ20190812163614809","JCYJ20200109114612308","JCYJ20210324120011030"] ; Shenzhen Key Laboratory of Ultrasound Imaging and Therapy[ZDSYS201802061806314] ; Guangdong Basic and Applied Basic Research Fund[2020A1515110011] ; Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province[2020B1212060051]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000742749100001

AMER CHEMICAL SOC

20220611585845

Brain ; Diagnosis ; Infrared devices ; Molecular biology ; Nanoprobes ; Surgery ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Optical Devices and Systems:741.3 ; Imaging Techniques:746 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

1.Chinese Acad Sci, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen Inst Adv Technol,Shenzhen Key Lab Ultras, CAS Key Lab Hlth Informat,Inst Biomed & Hlth Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, SUSTech Acad Adv Interdisciplinary Studies, Dept Biomed Engn, Shenzhen 518055, Peoples R China
3.Guangzhou Univ Chinese Med, Shenzhen Hosp, Dept Ultrasonog, Shenzhen 518034, Peoples R China

Gao, Duyang,Li, Yaxi,Wu, Yayun,et al. p Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging[J]. ACS Applied Materials & Interfaces,2022.

Gao, Duyang.,Li, Yaxi.,Wu, Yayun.,Liu, Yu.,Hu, Dehong.,...&Sheng, Zonghai.(2022).p Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging.ACS Applied Materials & Interfaces.

Gao, Duyang,et al."p Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging".ACS Applied Materials & Interfaces (2022).