Lateral Inhibition is a Neural Mechanism Underlying Mismatch Negativity

Gu, Feng1; Wong, Lena1; Chen, Fei2; Huang, Wan-Ting1; Wang, Lei2; Hu, A-Xu3

2018-08-10

10.1016/j.neuroscience.2018.06.009

NEUROSCIENCE   影响因子和分区

0306-4522

1873-7544

The human auditory change detection response known as mismatch negativity (MMN) is an auditory event-related potential that has been extensively used to investigate various aspects of human brain function and dysfunction. However, two competing views of the neural mechanism that underlie MMN have been a subject of debate for decades. The sensory memory hypothesis claims that the MMN reflects sensory memory-based change detection. The adaptation hypothesis argues that neural adaptation and lateral inhibition can fully explain the MMN. To date, there remains a lack of empirical evidence exploring whether lateral inhibition underlies MMN, which is a critical assumption of the adaptation hypothesis. In this study, an oddball paradigm was developed in which tone-pairs composed of two sinusoidal tones were presented as standards and deviants (e.g., a 330 Hz-392 Hz tone-pair was presented as standard, and a 392 Hz-330 Hz tone-pair was presented as deviant). The paradigm expected that two successive MMNs would be elicited by the two successive acoustic deviations in the deviant tone pairs, but when the two tones composing the tone-pairs were close in frequency, the first MMN would be attenuated in amplitude due to lateral inhibition. The results demonstrate that only one (the second) MMN was observed when the two tones were close in frequency (330 Hz and 392 Hz), but two MMNs were observed when the two tones were distant in frequency (330 Hz and 3135 Hz). These results suggest that lateral inhibition is a neural mechanism that underlies the MMN response. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

neural adaptation oddball auditory processing pitch change detection sensory memory

SCI ; SSCI

英语

其他

Gansu Province Youth Science and Technology Fund Project[156RJYA277]

Neurosciences & Neurology

Neurosciences

WOS:000438316600004

PERGAMON-ELSEVIER SCIENCE LTD

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Univ Hong Kong, Div Speech & Hearing Sci, Hong Kong, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen, Peoples R China
3.Northwest Minzu Univ, Key Lab Chinas Natl Linguist Informat Technol, Lanzhou, Gansu, Peoples R China

Gu, Feng,Wong, Lena,Chen, Fei,et al. Lateral Inhibition is a Neural Mechanism Underlying Mismatch Negativity[J]. NEUROSCIENCE,2018,385:38-46.

Gu, Feng,Wong, Lena,Chen, Fei,Huang, Wan-Ting,Wang, Lei,&Hu, A-Xu.(2018).Lateral Inhibition is a Neural Mechanism Underlying Mismatch Negativity.NEUROSCIENCE,385,38-46.

Gu, Feng,et al."Lateral Inhibition is a Neural Mechanism Underlying Mismatch Negativity".NEUROSCIENCE 385(2018):38-46.