The in vivo action of chronic bisphenol F showing potential immune disturbance in juvenile common carp (Cyprinus carpio)

Qiu, Wenhui1; Zhan, Hongyan2; Tian, Yiqun1; Zhang, Ting1; He, Xin1; Luo, Shusheng1; Xu, Hai3; Zheng, Chunmiao1,2

2018-08

10.1016/j.chemosphere.2018.04.105

CHEMOSPHERE   影响因子和分区

0045-6535

1879-1298

Bisphenol F (BPF) has been increasingly introduced into industrial applications as a replacement for bisphenol A (BPA), and has emerged as a ubiquitous environmental contaminant worldwide. Few studies have assessed the in vivo toxicities of BPF, particularly long-term exposure toxicities. In the present study, we examined whether long-term BPF exposure in vivo would evoke oxidative stress in the immune system of juvenile common carp. The results suggested that BPF exposure increased ROS content, oxidative stress indices, complement component 3, and immunoglobulin M contents, as well as the expression of inflammatory cytokine genes. Moreover, higher levels of nf-?b p65 gene expression were correlated with the induced ROS content and NF-?B pathway-associated genes, a strong indication that the mode of action of BPF is related to the NF-?B signaling pathway. We also provide evidence that the effects of BPF are comparable to those of BPA with regards to regulation of the immune response in teleosts, and therefore suggest that such chemical analogs should be thoroughly evaluated for their potential toxicity before they can be considered as "safer" replacements. (C) 2018 Elsevier Ltd. All rights reserved.

Immune modulatory Bisphenol F Fish Nuclear factor-Kb signaling

SCI ; EI

英语

第一 ; 通讯

Southern University of Science and Technology[G01296001]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000439640900056

PERGAMON-ELSEVIER SCIENCE LTD

20182205247545

Biomarkers ; Fish ; Gene expression ; Immune system ; Phenols ; Toxicity

Bioengineering and Biology:461 ; Electric Filters:703.2 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

Web of Science

1.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen 518055, Guangdong, Peoples R China
2.Peking Univ, Inst Water Sci, Coll Engn, Beijing 100871, Peoples R China
3.Jiangsu Univ, Inst Environm Hlth & Ecol Secur, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China

Qiu, Wenhui,Zhan, Hongyan,Tian, Yiqun,et al. The in vivo action of chronic bisphenol F showing potential immune disturbance in juvenile common carp (Cyprinus carpio)[J]. CHEMOSPHERE,2018,205:506-513.

Qiu, Wenhui.,Zhan, Hongyan.,Tian, Yiqun.,Zhang, Ting.,He, Xin.,...&Zheng, Chunmiao.(2018).The in vivo action of chronic bisphenol F showing potential immune disturbance in juvenile common carp (Cyprinus carpio).CHEMOSPHERE,205,506-513.

Qiu, Wenhui,et al."The in vivo action of chronic bisphenol F showing potential immune disturbance in juvenile common carp (Cyprinus carpio)".CHEMOSPHERE 205(2018):506-513.