Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment

Adlat，Salah1,2; Hayel，Farooq2; Chen，Yang2,3; Sah，Rajiv Kumar2,4; Mar Oo，Zin2; Al-Azab，Mahmoud5; Zun Zaw Myint，May2; Bahadar，Noor2; Binta Bah，Fatoumata2; Mi，Nasser1; Safi，Mohammed6; Feng，Xuechao2; Zhu，Ping1; Zheng，Yaowu2,7

2022-04-01

10.1016/j.intimp.2022.108559

INTERNATIONAL IMMUNOPHARMACOLOGY   影响因子和分区

1567-5769

1878-1705

Cancer is caused by abnormal cell growth and metastasis to other tissues. Development of cancers is complex and underlining mechanisms are mostly unknown. Disco-interacting protein 2 homolog B (DIP2B) is a member of Dip2. There have been reports suggesting that Dip2B may participate in tumor growth and development. However, direct link between DIP2B and cancer development is missing. In this study, Dip2b heterozygous knockout mouse model was used to investigate tumor growth and metastasis. Results show that one allele knockout of Dip2B significantly promoted tumor growth and metastasis, decreased tumor cell apoptosis and reduced immune cell infiltration in tumors, most likely by altering immune system that includes reduction of macrophage and cytotoxic T-cells infiltration into tumor microenvironment.

B16F10 Dip2B Metastasis RNA seq Tumor

SCI

英语

其他

National Natural Science Foundation of China[81270953] ; Natural Science Foundation of Jilin Province["20160101344JC","20200201127JC"] ; Science and Technology Project of Jilin Provincial Education Department[JJKH20180023KJ]

Immunology ; Pharmacology & Pharmacy

Immunology ; Pharmacology & Pharmacy

WOS:000793212500001

ELSEVIER

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85123359982

Scopus

1.Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,510100,China
2.Transgenic Research Center,School of Life Sciences,Northeast Normal University,Changchun,130024,China
3.School of Life Sciences,Xuzhou Medical University,Xuzhou,Jiangsu,221004,China
4.School of Medicine,Southern University of Science and Technology,Shenzhen,518005,China
5.Department of Immunology,Guangzhou Institute of Pediatrics,Guangzhou Women and Children's Medical Centre,Guangzhou Medical University,Guangzhou,510623,China
6.Department of Oncology,First Affiliated Hospital of Dalian Medical University,Dalian,China
7.Cardiovascular Research Institute,University of California,San Francisco,94158,United States

Adlat，Salah,Hayel，Farooq,Chen，Yang,et al. Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2022,105.

Adlat，Salah.,Hayel，Farooq.,Chen，Yang.,Sah，Rajiv Kumar.,Mar Oo，Zin.,...&Zheng，Yaowu.(2022).Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment.INTERNATIONAL IMMUNOPHARMACOLOGY,105.

Adlat，Salah,et al."Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment".INTERNATIONAL IMMUNOPHARMACOLOGY 105(2022).