Current progress in the controlled synthesis and biomedical applications of ultrasmall (< 10 nm) NaREF4 nanoparticles

Li, Chunxia1; Xu, Lili1; Liu, Zihua1; Li, Zhengquan1; Quan, Zewei3; Al Kheraif, Abdulaziz A.4; Lin, Jun2,4

2018-07-14

10.1039/c8dt00258d

DALTON TRANSACTIONS   影响因子和分区

1477-9226

1477-9234

The design and fabrication of rare earth upconversion nanoparticle (UCNP)-based nanomedical platforms have evoked increasing interest. However, their bio-safety is always the most worrisome problem. Most nanoparticles can accumulate in the internal organs, leading to acute toxicity, a long-term inflammatory response, or even fibrosis and cancer. In contrast, ultrasmall (sub-10 nm) nanoparticles have minimal safety risk because they can escape from macrophages, pass biological barriers, and be easily degraded or excreted from the body. In this review, we mainly introduce new progress in preparation strategies, imaging and drug delivery with regards to ultrasmall UCNPs, with an emphasis on rare earth fluorides, NaREF4. Finally, we discuss the future outlook and challenges relating to ultrasmall UCNPs.

SCI ; EI

英语

通讯

Key Research Program Of Frontier Sciences of CAS[YZDY-SSW-JSC018]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000437317700005

ROYAL SOC CHEMISTRY

20182805528925

Fluorine compounds ; Medical applications ; Nanoparticles ; Rare earths ; Safety engineering ; Synthesis (chemical)

Nanotechnology:761 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Safety Engineering:914 ; Solid State Physics:933

CHEMISTRY

Web of Science

1.Zhejiang Normal Univ, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
4.King Saud Univ, Coll Appl Med Sci, Dent Hlth Dept, Riyadh, Saudi Arabia

Li, Chunxia,Xu, Lili,Liu, Zihua,et al. Current progress in the controlled synthesis and biomedical applications of ultrasmall (< 10 nm) NaREF4 nanoparticles[J]. DALTON TRANSACTIONS,2018,47(26):8538-8556.

Li, Chunxia.,Xu, Lili.,Liu, Zihua.,Li, Zhengquan.,Quan, Zewei.,...&Lin, Jun.(2018).Current progress in the controlled synthesis and biomedical applications of ultrasmall (< 10 nm) NaREF4 nanoparticles.DALTON TRANSACTIONS,47(26),8538-8556.

Li, Chunxia,et al."Current progress in the controlled synthesis and biomedical applications of ultrasmall (< 10 nm) NaREF4 nanoparticles".DALTON TRANSACTIONS 47.26(2018):8538-8556.