Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation

Sang, Wei1; Zhong, Zhangfeng1,4; Linghu, Kegang1; Xiong, Wei1; Tse, Anfernee Kai Wing5; Cheang, Wai San1; Yu, Hua1,2,3,6; Wang, Yitao1,7

2018-07-05

10.1186/s13020-018-0193-x

Chinese Medicine   影响因子和分区

1749-8546

Background: Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory effects of SP were associated with the toll-like receptors (TLRs)-mediated nuclear factor-kB (NF-kB) and the mitogen-activated protein kinase (MAPK) signaling pathways.

Siegesbeckia pubescens Makino Pam(3)CSK(4) Inflammation Toll-like receptor 1/2 NF-kappa B

SCI

英语

其他

State Key Laboratory of Quality Research in Chinese Medicine of University of Macau[SKL-QRCM-2014-2016]

Integrative & Complementary Medicine ; Pharmacology & Pharmacy

Integrative & Complementary Medicine ; Pharmacology & Pharmacy

WOS:000437441000001

BMC

Web of Science

1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
2.HKBU Shenzhen Res Ctr, Shenzhen, Guangdong, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
4.Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang, Peoples R China
5.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Guangdong, Peoples R China
6.Univ Macau, Inst Chinese Med Sci, Room 8008,Bldg N22,Ave Univ, Taipa, Macao, Peoples R China
7.Univ Macau, Inst Chinese Med Sci, Room 1050,Bldg N22,Ave Univ, Taipa, Macao, Peoples R China

Sang, Wei,Zhong, Zhangfeng,Linghu, Kegang,et al. Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation[J]. Chinese Medicine,2018,13.

Sang, Wei.,Zhong, Zhangfeng.,Linghu, Kegang.,Xiong, Wei.,Tse, Anfernee Kai Wing.,...&Wang, Yitao.(2018).Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation.Chinese Medicine,13.

Sang, Wei,et al."Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation".Chinese Medicine 13(2018).