南方科技大学知识苑(SUSTech KC): Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

题名	Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins
作者	Yin, Congcong 1; Wu, Weilong 1; Hu, Yang 1; Tan, Xuefeng 2; You, Cai 1; Liu, Yuanhua 1; Chen, Ziyi 1; Dong, Xiu-Qin 1; Zhang, Xumu1,2
通讯作者	Dong, Xiu-Qin; Zhang, Xumu
发表日期	2018-06-05
DOI	10.1002/adsc.201800267
发表期刊	ADVANCED SYNTHESIS & CATALYSIS 影响因子和分区
ISSN	1615-4150
EISSN	1615-4169
卷号	360 期号:11页码:2119-2124
摘要	Iridium-catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to > 99% conversion, 99% yield, > 99% ee). Moreover, gram-scale experiment was performed well in the presence of just 0.005 mol% (S/C = 20 000) Ir/f-amphox catalyst with 99% yield and > 99% ee.
关键词	Asymmetric hydrogenation halogenated ketones chiral halohydrins enantioselectivity chiral tridentate ligand
相关链接	[来源记录]
收录类别	SCI ; CCR
语种	英语
学校署名	通讯
资助项目	Wuhan Morning Light Plan of Youth Science and Technology[2017050304010307]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000434349400008
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：39
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/27627
专题	理学院_化学系
作者单位	1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
通讯作者单位	化学系
推荐引用方式 GB/T 7714	Yin, Congcong,Wu, Weilong,Hu, Yang,et al. Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins[J]. ADVANCED SYNTHESIS & CATALYSIS,2018,360(11):2119-2124.
APA	Yin, Congcong.,Wu, Weilong.,Hu, Yang.,Tan, Xuefeng.,You, Cai.,...&Zhang, Xumu.(2018).Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins.ADVANCED SYNTHESIS & CATALYSIS,360(11),2119-2124.
MLA	Yin, Congcong,et al."Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins".ADVANCED SYNTHESIS & CATALYSIS 360.11(2018):2119-2124.