南方科技大学知识苑(SUSTech KC): The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway

题名	The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway
作者	Gu, Hao 1,2; Do, Dang Vinh 3,7; Liu, Xinyu 1; Xu, Luang 1; Su, Yixun 2,3; Nah, Jie Min 6; Wong, Yuqian 1; Li, Ying 1; Sheng, Na 5; Tilaye, Gebreselassie Addisu 2,3; Yang, Henry 1; Guo, Huili 6; Yan, Jun 5; Fu, Xin-Yuan 1,2,3,4
通讯作者	Gu, Hao; Fu, Xin-Yuan
发表日期	2018-06-05
DOI	10.1016/j.stemcr.2018.03.022
发表期刊	Stem Cell Reports 影响因子和分区
ISSN	2213-6711
卷号	10 期号:6页码:1807-1820
摘要	The capacity of embryonic stem cells (ESCs) to differentiate into all lineages of mature organism is precisely regulated by cellular signaling factors. STAT3 is a crucial transcription factor that plays a central role in maintaining ESC identity. However, the underlying mechanism by which STAT3 directs differentiation is still not completely understood. Here, we show that STAT3 positively regulates gene expression of methyltransferase-like protein 8 (Mettl8) in mouse ESCs. We found that METTL8 is dispensable for pluripotency but affects ESC differentiation. Subsequently, we discovered that METTL8 interacts with Mapkbp1's mRNA, which is an intermediate factor in c-Jun N-terminal kinase (JNK) signaling, and inhibits the translation of the mRNA. Thereby, METTL8 prohibits the activation of JNK signaling and enhances the differentiation of mouse ESCs. Collectively, our study uncovers a STAT3 target, Mettl8, which regulates mouse ESC differentiation via JNK signaling.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Ministry of Education[R-713-000-169-112]
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000434629400012
出版者	CELL PRESS
来源库	Web of Science
引用统计	被引频次[WOS]：14
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/27628
专题	生命科学学院_生物系
作者单位	1.Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore 2.Natl Univ Singapore, Ctr Life Sci, Singapore 117456, Singapore 3.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117456, Singapore 4.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China 5.Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China 6.Inst Mol & Cell Biol, Singapore 138673, Singapore 7.Genome Inst Singapore, Singapore 138672, Singapore
通讯作者单位	生物系
推荐引用方式 GB/T 7714	Gu, Hao,Do, Dang Vinh,Liu, Xinyu,et al. The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway[J]. Stem Cell Reports,2018,10(6):1807-1820.
APA	Gu, Hao.,Do, Dang Vinh.,Liu, Xinyu.,Xu, Luang.,Su, Yixun.,...&Fu, Xin-Yuan.(2018).The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway.Stem Cell Reports,10(6),1807-1820.
MLA	Gu, Hao,et al."The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway".Stem Cell Reports 10.6(2018):1807-1820.