Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone

Sun, Kai1; Yang, Yingkun1; Zhou, Hua1; Yin, Shengyan1; Qin, Weiping1; Yu, Jiangbo3; Chiu, Daniel T.3; Yuan, Zhen4; Zhang, Xuanjun4; Wu, Changfeng2

2018-06

10.1021/acsnano.8b02188

ACS Nano   影响因子和分区

1936-0851

1936-086X

Optical methods such as absorptiometry, fluorescence, and surface plasmon resonance have long been explored for sensing glucose. However, these schemes have not had the clinical success of electrochemical methods for point-of-care testing because of the limited performance of optical sensors and the bulky instruments they require. Here, we show that an ultrasensitive optical transducer can be used for wireless glucose monitoring via a smartphone. The optical transducer combines oxygen sensitive polymer dots (Pdots) with glucose oxidase that sensitively detect glucose when oxygen is consumed in the glucose oxidation reaction. By judicious design of the Pdots with ultralong phosphorescence lifetime, the transducer exhibited a significantly enhanced sensitivity by 1 order of magnitude as compared to the one in a previous study. As a result, the optical images of subcutaneous glucose level obtained with the smartphone camera could be utilized to clearly distinguish between euglycemia and hyperglycemia. We further developed an image processing algorithm and a software application that was installed on a smartphone. Real-time dynamic glucose monitoring in live mice was demonstrated with the smartphone and the implanted Pdot transducer.

diabetes continuous glucose monitoring semiconducting polymer dots fluorescence imaging smartphone

SCI ; EI

英语

NI论文

通讯

Shenzhen Science and Technology Innovation Commission[JCYJ20170307110157501]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000436910200012

AMER CHEMICAL SOC

20181905168449

Application programs ; Geometrical optics ; Glucose ; Glucose sensors ; Image processing ; Instrument testing ; Optical data processing ; Oxygen ; Polymeric implants ; Smartphones ; Surface plasmon resonance ; Transducers

Biology:461.9 ; Biomedical Equipment, General:462.1 ; Telephone Systems and Equipment:718.1 ; Computer Software, Data Handling and Applications:723 ; Data Processing and Image Processing:723.2 ; Light/Optics:741.1 ; Chemical Products Generally:804 ; Organic Compounds:804.1

Web of Science

1.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
3.Univ Washington, Dept Chem & Bioengn, Seattle, WA 98195 USA
4.Univ Macau, Fac Hlth Sci, Taipa 999078, Macau, Peoples R China

Sun, Kai,Yang, Yingkun,Zhou, Hua,et al. Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone[J]. ACS Nano,2018,12(6):5176-5184.

Sun, Kai.,Yang, Yingkun.,Zhou, Hua.,Yin, Shengyan.,Qin, Weiping.,...&Wu, Changfeng.(2018).Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone.ACS Nano,12(6),5176-5184.

Sun, Kai,et al."Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone".ACS Nano 12.6(2018):5176-5184.