Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe

Wang, Weizhi1,2; Ma, Zhuoran2; Zhu, Shoujun2; Wan, Hao2; Yue, Jingying2; Ma, Huilong3; Ma, Rui3; Yang, Qinglai3; Wang, Zihua1,4; Li, Qian4; Qian, Yixia1; Yue, Chunyan1; Wang, Yuehua1; Fan, Linyang1; Zhong, Yeteng2; Zhou, Ying2; Gao, Hongpeng2; Ruan, Junshan2; Hu, Zhiyuan1,5,6; Liang, Yongye3; Dai, Hongjie2

2018-05-29

10.1002/adma.201800106

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (approximate to 87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy.

molecular imaging peptide probe renal-excretion second near-infrared window tumor targeting

SCI ; EI

英语

NI论文

通讯

Shenzhen Peacock Program[KQTD20140630160825828]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000434034100025

WILEY-V C H VERLAG GMBH

20182305274062

Antibodies ; Diagnosis ; Diseases ; Fluorescence imaging ; Infrared devices ; Mammals ; Peptides ; Physiology ; Probes ; Stem cells ; Tumors

Bioengineering and Biology:461 ; Imaging Techniques:746

MATERIALS SCIENCE

Web of Science

1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
2.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
3.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China
6.Fujian Med Univ, Sch Basic Med Sci, Ctr Neurosci Res, Fuzhou 350108, Fujian, Peoples R China

Wang, Weizhi,Ma, Zhuoran,Zhu, Shoujun,et al. Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe[J]. ADVANCED MATERIALS,2018,30(22).

Wang, Weizhi.,Ma, Zhuoran.,Zhu, Shoujun.,Wan, Hao.,Yue, Jingying.,...&Dai, Hongjie.(2018).Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe.ADVANCED MATERIALS,30(22).

Wang, Weizhi,et al."Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe".ADVANCED MATERIALS 30.22(2018).