Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery

Chen, Haobin1,2; Fang, Xiaofeng2; Jin, Yue1; Hu, Xin1; Yin, Min3,4; Men, Xiaoju2; Chen, Nan3,4; Fan, Chunhai3,4; Chiu, Daniel T.5; Wan, Youzhong1; Wu, Changfeng2

2018-05-24

10.1002/smll.201800239

Small   影响因子和分区

1613-6810

1613-6829

Nanocavities composed of lipids and block polymers have demonstrated great potential in biomedical applications such as sensors, nanoreactors, and delivery vectors. However, it remains a great challenge to produce nanocavities from fluorescent semiconducting polymers owing to their hydrophobic rigid polymer backbones. Here, we describe a facile, yet general strategy that combines photocrosslinking with nanophase separation to fabricate multicolor, water-dispersible semiconducting polymer nanocavities (PNCs). A photocrosslinkable semiconducting polymer is blended with a porogen such as degradable macromolecule to form compact polymer dots (Pdots). After crosslinking the polymer and removing the porogen, this approach yields semiconducting polymer nanospheres with open cavities that are tunable in diameter. Both small molecules and macromolecules can be loaded in the nanocavities, where molecular size can be differentiated by the efficiency of the energy transfer from host polymer to guest molecules. An anticancer drug doxorubicin (Dox) is loaded into the nanocavities and the intracellular release is monitored in real time by the fluorescence signal. Finally, the efficient delivery of small interfering RNA (siRNA) to silence gene expression without affecting cell viability is demonstrated. The combined features of bright fluorescence, tunable cavity, and efficient drug/siRNA delivery makes these nanostructures promising for biomedical imaging and drug delivery.

delivery vectors fluorescent probes host-guest interaction nanocavities semiconducting polymers

SCI ; EI

英语

通讯

Shenzhen Science and Technology Innovation Commission[JCYJ20170307110157501]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000434173300016

WILEY-V C H VERLAG GMBH

20182305283596

Block copolymers ; Controlled drug delivery ; Crosslinking ; Energy transfer ; Fluorescence ; Functional polymers ; Gene expression ; Macromolecules ; Medical applications ; Medical imaging ; Targeted drug delivery

Biology:461.9 ; Semiconducting Materials:712.1 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Chemical Reactions:802.2 ; Polymeric Materials:815.1

Web of Science

1.Jilin Univ, Sch Life Sci, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China
5.Univ Washington, Dept Chem & Bioengn, Seattle, WA 98195 USA

Chen, Haobin,Fang, Xiaofeng,Jin, Yue,et al. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery[J]. Small,2018,14(21).

Chen, Haobin.,Fang, Xiaofeng.,Jin, Yue.,Hu, Xin.,Yin, Min.,...&Wu, Changfeng.(2018).Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.Small,14(21).

Chen, Haobin,et al."Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery".Small 14.21(2018).