Thermally activated delayed fluorescence organic dots for two-photon fluorescence lifetime imaging

He, Tingchao1; Ren, Can1; Li, Zhuohua2; Xiao, Shuyu1; Li, Junzi1; Lin, Xiaodong1; Ye, Chuanxiang1; Zhang, Junmin2; Guo, Lihong3,4; Hu, Wenbo3,4; Chen, Rui5

2018-05-21

10.1063/1.5034375

APPLIED PHYSICS LETTERS   影响因子和分区

0003-6951

1077-3118

Autofluorescence is a major challenge in complex tissue imaging when molecules present in the biological tissue compete with the fluorophore. This issue may be resolved by designing organic molecules with long fluorescence lifetimes. The present work reports the two-photon absorption (TPA) properties of a thermally activated delayed fluorescence (TADF) molecule with carbazole as the electron donor and dicyanobenzene as the electron acceptor (i.e., 4CzIPN). The results indicate that 4CzIPN exhibits a moderate TPA cross-section (similar to 9 x 10(-50) cm(4) s photon(-1)), high fluorescence quantum yield, and a long fluorescence lifetime (similar to 1.47 mu s). 4CzIPN was compactly encapsulated into an amphiphilic copolymer via nanoprecipitation to achieve water-soluble organic dots. Interestingly, 4CzIPN organic dots have been utilized in applications involving two-photon fluorescence lifetime imaging (FLIM). Our work aptly demonstrates that TADF molecules are promising candidates of nonlinear optical probes for developing next-generation multiphoton FLIM applications. Published by AIP Publishing.

SCI ; EI

英语

NI论文

其他

Natural Science Foundation of SZU[827-000069]

Physics

Physics, Applied

WOS:000433140900002

AMER INST PHYSICS

20182205255430

Luminescence of organic solids ; Molecules ; Photons ; Tissue ; Two photon processes

Biological Materials and Tissue Engineering:461.2 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Atomic and Molecular Physics:931.3

PHYSICS

Web of Science

1.Shenzhen Univ, Coll Phys & Energy, Shenzhen 518060, Peoples R China
2.Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China
3.Nanjing Tech Univ NanjingTech, KLOFE, 30 South Puzhu Rd, Nanjing 211800, Jiangsu, Peoples R China
4.Nanjing Tech Univ NanjingTech, IAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, 30 South Puzhu Rd, Nanjing 211800, Jiangsu, Peoples R China
5.Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen 518055, Peoples R China

He, Tingchao,Ren, Can,Li, Zhuohua,et al. Thermally activated delayed fluorescence organic dots for two-photon fluorescence lifetime imaging[J]. APPLIED PHYSICS LETTERS,2018,112(21).

He, Tingchao.,Ren, Can.,Li, Zhuohua.,Xiao, Shuyu.,Li, Junzi.,...&Chen, Rui.(2018).Thermally activated delayed fluorescence organic dots for two-photon fluorescence lifetime imaging.APPLIED PHYSICS LETTERS,112(21).

He, Tingchao,et al."Thermally activated delayed fluorescence organic dots for two-photon fluorescence lifetime imaging".APPLIED PHYSICS LETTERS 112.21(2018).