| 题名 | PCGF5 is required for neural differentiation of embryonic stem cells |
| 作者 | |
| 通讯作者 | Yao, Hongjie |
| 发表日期 | 2018-05-15
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| DOI | |
| 发表期刊 | |
| ISSN | 2041-1723
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| 卷号 | 9 |
| 摘要 | Polycomb repressive complex 1 (PRC1) is an important regulator of gene expression and development. PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has been sub-classified into six major complexes based on the presence of a PCGF subunit. Here, we report that PCGF5, one of six PCGF paralogs, is an important requirement in the differentiation of mouse embryonic stem cells (mESCs) towards a neural cell fate. Although PCGF5 is not required for mESC self-renewal, its loss blocks mESC neural differentiation by activating the SMAD2/TGF-beta signaling pathway. PCGF5 loss-of-function impairs the reduction of H2AK119ub1 and H3K27me3 around neural specific genes and keeps them repressed. Our results suggest that PCGF5 might function as both a repressor for SMAD2/TGF-beta signaling pathway and a facilitator for neural differentiation. Together, our findings reveal a critical context-specific function for PCGF5 in directing PRC1 to control cell fate. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 重要成果 | NI期刊
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| 学校署名 | 其他
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| 资助项目 | Focused Innovations Scheme[1907307]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:000432114200001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：52
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/27719 |
| 专题 | 生命科学学院_生物系 |
| 作者单位 | 1.Guangzhou Med Univ, Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, CAS Key Lab Regenerat Biol,Joint Sch Life Sci, Guangzhou 510530, Guangdong, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, CAS Ctr Excellence Mol Cell Sci, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China 3.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Chem Pathol, Hong Kong 999077, Hong Kong, Peoples R China 4.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Peoples R China 5.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol, Hong Kong 999077, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Yao, Mingze,Zhou, Xueke,Zhou, Jiajian,et al. PCGF5 is required for neural differentiation of embryonic stem cells[J]. Nature Communications,2018,9.
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| APA |
Yao, Mingze.,Zhou, Xueke.,Zhou, Jiajian.,Gong, Shixin.,Hu, Gongcheng.,...&Yao, Hongjie.(2018).PCGF5 is required for neural differentiation of embryonic stem cells.Nature Communications,9.
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| MLA |
Yao, Mingze,et al."PCGF5 is required for neural differentiation of embryonic stem cells".Nature Communications 9(2018).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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