Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery

Zhao, Haoran1; Yuan, Xuexia1; Yu, Jiantao1; Huang, Yishun1; Shao, Chen1; Xiao, Fan1; Lin, Li1; Li, Yan2; Tian, Leilei1

2018-05-09

10.1021/acsami.8b01932

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

Functional nucleic acids, which can target cancer cells and realize stimuli-responsive drug delivery in tumor microenvironment, have been widely applied for anticancer chemotherapy. At present, high cost, unsatisfactory biostability, and complicated fabrication process are the main limits for the development of DNA-based drug-delivery nanocarriers. Here, a doxorubicin (Dox)-delivery nanoparticle for tumor-targeting chemotherapy is developed taking advantage of rolling circle amplification (RCA) technique, by which a high quantity of functional DNAs can be efficiently collected. Furthermore, Mg2+, a major electrolyte in human body showing superior biocompatibility, can sufficiently condense the very long sequence of an RCA product and better preserve its functions. The resultant DNA nanoparticle exhibits a high biostability, making it a safe and ideal nanomaterial for in vivo application. Through cellular and in vivo experiments, we thoroughly demonstrate that this kind of Mg2+-stabilized multifunctional DNA nanoparticles can successfully realize tumor-targeted Dox delivery. Overall, exploiting RCA technique and Mg2+ condensation, this new strategy can fabricate nanoparticles with a nontoxic composition through a simple fabrication process and provides a good way to preserve and promote DNA functions, which will show a broad application potential in the biomedical field.

tumor-targeted chemotherapy DNA nanostructure drug delivery stimuli-responsive release aptamer

SCI ; EI

英语

第一 ; 通讯

Shenzhen Key Laboratory of Cell Microenvironment[ZDSYS20140509142721429]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000432205800012

AMER CHEMICAL SOC

20181905151861

Biocompatibility ; Chemotherapy ; Controlled drug delivery ; Diseases ; DNA ; Drug delivery ; Electrolytes ; Magnesium ; Nanoparticles ; Nucleic acids ; Tumors

Bioengineering and Biology:461 ; Magnesium and Alloys:542.2 ; Electric Batteries and Fuel Cells:702 ; Nanotechnology:761 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804 ; Solid State Physics:933

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Dept Biol, Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis R, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China

Zhao, Haoran,Yuan, Xuexia,Yu, Jiantao,et al. Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery[J]. ACS Applied Materials & Interfaces,2018,10(18):15418-15427.

Zhao, Haoran.,Yuan, Xuexia.,Yu, Jiantao.,Huang, Yishun.,Shao, Chen.,...&Tian, Leilei.(2018).Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery.ACS Applied Materials & Interfaces,10(18),15418-15427.

Zhao, Haoran,et al."Magnesium-Stabilized Multifunctional DNA Nanoparticles for Tumor-Targeted and pH-Responsive Drug Delivery".ACS Applied Materials & Interfaces 10.18(2018):15418-15427.