Design and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes

You, Cai1,2; Li, Shuailong1,2; Li, Xiuxiu1,2; Lan, Jialing4; Yang, Yuhong4; Chung, Lung Wa4; Lv, Hui1,2,3; Zhang, Xumu1,2,4

2018-04-18

10.1021/jacs.8b00275

Journal of the American Chemical Society   影响因子和分区

0002-7863

A series of novel hybrid phosphorus ligands were designed and applied to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes. By employing the new catalyst, linear aldehydes with beta-chirality can be prepared with high yields and enantioselectivities under mild conditions. Furthermore, catalyst loading as low as 0.05 mol % furnished the desired product in good yield and undiminished selectivity, demonstrating the efficiency of this transformation in large-scale synthesis.

SCI ; EI ; IC ; CCR

英语

NI期刊

通讯

Important Sci-Tech Innovative Project of Hubei Province[2015ACA058]

Chemistry

Chemistry, Multidisciplinary

WOS:000430642000006

AMER CHEMICAL SOC

20181705040948

Catalysis ; Enantioselectivity ; Hydrocarbons ; Hydroformylation ; Ligands ; Phosphorus

Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1

Web of Science

1.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China
2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
3.Wuhan Univ, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
4.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China

You, Cai,Li, Shuailong,Li, Xiuxiu,et al. Design and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes[J]. Journal of the American Chemical Society,2018,140(15):4977-4981.

You, Cai.,Li, Shuailong.,Li, Xiuxiu.,Lan, Jialing.,Yang, Yuhong.,...&Zhang, Xumu.(2018).Design and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes.Journal of the American Chemical Society,140(15),4977-4981.

You, Cai,et al."Design and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes".Journal of the American Chemical Society 140.15(2018):4977-4981.