Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort

Lai, Kefang1; Zhan, Wenzhi1; Wu, Feng2; Zhang, Yunhui3; Lin, Lin4; Li, Wen5; Yi, Fang1; Jiang, Ziyu1; Dai, Yuanrong6; Li, Suyun7; Lin, Jiangtao8; Yuan, Yadong9; Jiang, Yong10; Qiu, Chen11; Zhao, Limin12; Chen, Meihua13; Qiu, Zhongmin14; Li, Hu1; Chen, Ruchong1; Luo, Wei1; Xie, Jiaxing1; Guo, Chunxing1; Jiang, Mei1; Yang, Xiaohong15; Shi, Guochao16; Sun, Dejun17; Chen, Rongchang1,11; Chung, Kian Fan18; Shen, Huahao5; Zhong, Nanshan1

2022-01-21

10.3389/fmed.2021.807385

FRONTIERS IN MEDICINE   影响因子和分区

2296-858X

BackgroundThe AtyPical Asthma in China (APAC) cohort is a multi-center prospective, observational cohort set-up to investigate the clinical, pathophysiological features, prognosis, and mechanisms of cough variant asthma (CVA). ObjectivesTo present the characteristics of newly physician-diagnosed adults with CVA (n = 328) compared to mild-moderate classic asthma (CA, n = 206). Methods and Main ResultsCVA subjects showed a higher proportion of female (67.1 vs. 55.3%, P = 0.0084), abnormal laryngopharyngeal sensations (71 vs. 51%, p < 0.0001) than CA, but presented with near normal spirometry and higher methacholine PD20-FEV1 values [4.2 (1, 8.6) vs. 0.8 (0.4, 4.7), P < 0.0001]. Lower fractional exhaled nitric oxide (FENO) levels [38.5 (19.8, 72.5) vs. 53. (28.5, 92.2), P = 0.0019], blood eosinophil counts [0.2 (0.1, 0.4) vs. 0.3 (0.2, 0.5), P = 0.0014], and sputum eosinophils [2.3 (0.3, 8.0) vs. 12.2 (2, 34.5), p < 0.0001] were found in CVA. Despite lower total serum IgE levels in CVA, there was similar proportion of atopy in both groups. The prevalence of cough in CA was 86.4%, while CVA reported more severe cough on Visual Analog Scale, Cough Evaluation Test, and Leicester Cough Questionnaire, similar anxiety and depression scores but better asthma control scores as reflected by Asthma Control Test compared to CA. No correlation was found between cough assessment outcomes and sputum eosinophil count, blood eosinophil count, FENO, spirometry variables, or PD20-FEV1. ConclusionCough variant asthma is distinctive from classic asthma in regard to clinical features, lung function, and airway inflammation. Quality of life is badly impaired as well in spite of better asthma control scores.

cough variant asthma (CVA) classic asthma (CA) airway inflammation bronchial hyperresponsiveness cough

SCI

英语

其他

General & Internal Medicine

Medicine, General & Internal

WOS:000751281900001

FRONTIERS MEDIA SA

Web of Science

1.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth,Natl Clin Res Ctr Resp D, Dept Pulm & Crit Care Med,State Key Lab Resp Dis, Guangzhou, Peoples R China
2.Huizhou Third Peoples Hosp, Dept Pulm & Crit Care Med, Huizhou, Peoples R China
3.First Peoples Hosp Yunnan Prov, Dept Pulm & Crit Care Med, Kunming, Peoples R China
4.Guangzhou Univ Chinese Med, Sch Clin 2, Guangdong Prov Acad Chinese Med Sci, Dept Pulm & Crit Care Med,Guangdong Prov Hosp Chi, Guangzhou, Peoples R China
5.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pulm & Crit Care Med,Key Lab Resp Dis Zhejia, Hangzhou, Peoples R China
6.Wenzhou Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Wenzhou, Peoples R China
7.Henan Univ Chinese Med, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhengzhou, Peoples R China
8.China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China
9.Hebei Med Univ, Hosp 2, Dept Pulm & Crit Care Med, Shijiazhuang, Peoples R China
10.Shenzhen Hosp Integrated Tradit Chinese & Western, Dept Resp & Crit Care Med, Shenzhen, Peoples R China
11.Jinan Univ, Clin Med Coll 2, Southern Univ Sci & Technol,Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Resp & Crit Care Med,Shenz, Shenzhen, Peoples R China
12.Peoples Hosp Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Resp & Crit Care Med, Zhengzhou, Peoples R China
13.Third Peoples Hosp Dongguan City, Songshan Lake Cent Hosp Dongguan City, Dept Pulm & Crit Care Med, Dongguan, Peoples R China
14.Tongji Univ, Tongji Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China
15.Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang Interstitial Lung Dis Clin Med Res Ctr, Dept Resp & Crit Care Med, Urumqi, Peoples R China
16.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
17.Inner Mongolia Autonomous Reg Peoples Hosp, Dept Pulm & Crit Care Med, Hohhot, Peoples R China
18.Royal Brompton & Harefield Fdn NHS Trust, Imperial Coll London, Natl Heart & Lung Inst, London, England

Lai, Kefang,Zhan, Wenzhi,Wu, Feng,et al. Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort[J]. FRONTIERS IN MEDICINE,2022,8.

Lai, Kefang.,Zhan, Wenzhi.,Wu, Feng.,Zhang, Yunhui.,Lin, Lin.,...&Zhong, Nanshan.(2022).Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort.FRONTIERS IN MEDICINE,8.

Lai, Kefang,et al."Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort".FRONTIERS IN MEDICINE 8(2022).