Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT

Liao, Xuejiao1,2; Li, Dapeng2,3; Liu, Zhi4; Ma, Zhenghua1; Zhang, Lina1; Dong, Jingke1; Shi, Yirong1; Gu, Xiaowen1; Zheng, Guangping5; Huang, Ling4; Yuan, Lijun3; Cao, Jing3; Shu, Dan2; Yang, Xiangyi2; He, Qing3; Li, Guobao4; Zhang, Zheng2,3; Liu, Lei3

2022-01-13

10.3389/fmed.2021.686878

FRONTIERS IN MEDICINE   影响因子和分区

2296-858X

Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge.Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement.Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time.Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions.

coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pulmonary sequelae follow-up computed tomography

SCI

英语

通讯

National Science Fund for Distinguished Young Scholars[82025022] ; Science and Technology Innovation Committee of Shenzhen Municipality[2020A1111350032] ; Sanming Project of Medicine in Shenzhen["SZSM201612025","SZSM201911009"] ; Novel Coronavirus prevention and control project for Guangdong province["2020B1111340030","2020B1111340026"]

General & Internal Medicine

Medicine, General & Internal

WOS:000749810200001

FRONTIERS MEDIA SA

Web of Science

1.Shenzhen Third Peoples Hosp, Dept Chron Follow UP, Shenzhen, Peoples R China
2.Shenzhen Third Peoples Hosp, Inst Hepatol, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China
4.Shenzhen Third Peoples Hosp, Dept Pulm Dis 3, Shenzhen, Peoples R China
5.Shenzhen Third Peoples Hosp, Dept Radiol, Shenzhen, Peoples R China

Liao, Xuejiao,Li, Dapeng,Liu, Zhi,et al. Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT[J]. FRONTIERS IN MEDICINE,2022,8.

Liao, Xuejiao.,Li, Dapeng.,Liu, Zhi.,Ma, Zhenghua.,Zhang, Lina.,...&Liu, Lei.(2022).Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT.FRONTIERS IN MEDICINE,8.

Liao, Xuejiao,et al."Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT".FRONTIERS IN MEDICINE 8(2022).