Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections

Espejo-Paeres, Carolina1; Arroyo Espliguero, Ramon2; Uribarri, Aitor3; Anton-Huguet, Berta4; Romero, Rodolfo5; Fernandez-Rozas, Inmaculada6; Manuel Becerra-Munoz, Victor7; Alfonso-Rodriguez, Emilio8; Huang, Jia9; Elizabeth Ortega-Armas, Maria10; Pepe, Martino11; Gonzalez, Adelina12; Bertolazzi, Marzia13; Cerrato, Enrico14; Quezada, Antonio15; Raposeiras-Roubin, Sergio16; Vedia, Oscar17; Feltes-Guzman, Gisela18; Akin, Ibrahim19,20; Carrero-Fernandez, Ana1; Macaya, Carlos17; Estrada, Vicente17; Nunez-Gil, Ivan J.17

2022-02-01

10.1016/j.cmi.2021.09.021

CLINICAL MICROBIOLOGY AND INFECTION   影响因子和分区

1198-743X

1469-0691

["Objectives: To identify predictors of poor prognosis in previously healthy young individuals admitted to hospital with coronavirus disease 2019 (COVID-19).","Methods: We studied a cohort of patients hospitalized with COVID-19. All patients without comorbidities, without usual treatments and <65 years old were selected from an international registry (HOPE-COVID-19, NCT04334291). We focused on baseline variables-symptoms and signs at admission-to analyse risk factors for poor prognosis. The primary end point was a composite of major adverse clinical events during hospitalization including mortality, mechanical ventilation, high-flow nasal oxygen therapy, prone, sepsis, systemic inflammatory response syndrome and embolic events.","Results: Overall, 773 healthy young patients were included. The primary composite end point was observed in 29% (225/773) and the overall mortality rate was 3.6% (28/773). In the combined event group, 75% (168/225) of patients were men and the mean age was 49 (+/- 11) years, whereas in the non- combined event group, the prevalence of male gender was 43% (238/548) and the mean age was 42 (+/- 13) years (p < 0.001 for both). On admission, respiratory insufficiency and cough were described in 51.4% (114/222) and 76% (170/223) of patients, respectively, in the combined event group, versus 7.9% (42/533) and 56% (302/543) of patients in the other group (p < 0.001 for both). The strongest independent predictor for the combined end point was desaturation (Spo t <92%) (OR 5.40; 95% CI 3.34-8.75; p < 0.001), followed by tachypnoea (OR 3.17; 95% CI 1.93-5.21; p < 0.001), male gender (OR 3.01; 95% CI 1.96-4.61; p < 0.001) and pulmonary infiltrates on chest X-ray at admission (OR 2.21; 95% CI 1.18-4.16; p 0.014).","Conclusions: Major adverse clinical events were unexpectedly high considering the baseline characteristics of the cohort. Signs of respiratory compromise at admission and male gender, were predictive for poor prognosis among young healthy patients hospitalized with COVID-19. (C) 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved."]

COVID-19 Mortality Lung disease Prognosis Healthy Young

SCI

英语

其他

Infectious Diseases ; Microbiology

Infectious Diseases ; Microbiology

WOS:000747878400017

ELSEVIER SCI LTD

IMMUNOLOGY

Web of Science

1.Hosp Univ Principe Asturias, Madrid, Spain
2.Hosp Univ Guadalajara, Guadalajara, Spain
3.Hosp Clin Univ Valladolid, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Valladolid, Spain
4.Hosp Univ La Paz, Madrid, Spain
5.Univ Europea Madrid, Hosp Univ Getafe, Madrid, Spain
6.Hosp Severo Ochoa, Leganes, Spain
7.Univ Malaga UMA, Hosp Univ Virgen Victoria, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Malaga, Spain
8.Inst Cardiol & Cirugia Cardiovasc, Havana, Cuba
9.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Peoples R China
10.Hosp Gen Norte Guayaquil IESS Ceibos, Guayaquil, Ecuador
11.Azienda Osped Univ Consorziale Policlin Bari, Bari, Italy
12.Hosp Univ Infanta Sofia, Madrid, Spain
13.St Andrea Hosp, Verdelli, Italy
14.San Luigi Gonzaga Univ Hosp, Turin, Italy
15.Univ Valencia, Hosp Clin Univ, Incl, Valencia, Spain
16.Univ Hosp Alvaro Cunqueiro, Vigo, Spain
17.Univ Complutense Madrid, Sanitaria Hosp Clin San Carlos IdISSC Madrid, Inst Invest, Hosp Clin San Carlos, Madrid, Spain
18.Hosp Nuestra Senora Amer, Madrid, Spain
19.Heidelberg Univ, Med Fac Mannheim, Dept Med 1, Mannheim, Germany
20.DZHK German Ctr Cardiovasc Res, Partner Site Heidelberg Mannheim, D-68167 Mannheim, Germany

Espejo-Paeres, Carolina,Arroyo Espliguero, Ramon,Uribarri, Aitor,et al. Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections[J]. CLINICAL MICROBIOLOGY AND INFECTION,2022,28(2).

Espejo-Paeres, Carolina.,Arroyo Espliguero, Ramon.,Uribarri, Aitor.,Anton-Huguet, Berta.,Romero, Rodolfo.,...&Nunez-Gil, Ivan J..(2022).Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections.CLINICAL MICROBIOLOGY AND INFECTION,28(2).

Espejo-Paeres, Carolina,et al."Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections".CLINICAL MICROBIOLOGY AND INFECTION 28.2(2022).