A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

Wan, Hao1,2; Yue, Jingying2; Zhu, Shoujun2; Uno, Takaaki2,3; Zhang, Xiaodong4,5; Yang, Qinglai1,6; Yu, Kuai2; Hong, Guosong2; Wang, Junying4,5; Li, Lulin7; Ma, Zhuoran2; Gao, Hongpeng2; Zhong, Yeteng2; Su, Jessica2; Antaris, Alexander L.2; Xia, Yan2; Luo, Jian7,8; Liang, Yongye1; Dai, Hongjie2

2018-03-21

10.1038/s41467-018-03505-4

Nature Communications   影响因子和分区

2041-1723

Fluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000-1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II > 1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to similar to 1.3mm and sub-10 mu m high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.

SCI

英语

ESI高被引 ; NI期刊 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引

第一 ; 通讯

Shenzhen Basic Research Funding[JCYJ 20170307151634428]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000427929200002

NATURE PUBLISHING GROUP

Web of Science

1.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
3.JSR Corp Adv Mat Res Labs, 100 Kawajiri Cho, Yokaichi, Mie 5108552, Japan
4.Tianjin Univ, Sch Sci, Dept Phys, Tianjin 300350, Peoples R China
5.Tianjin Univ, Sch Sci, Tianjin Key Lab Low Dimens Mat Phys & Preparing T, Tianjin 300350, Peoples R China
6.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
7.VA Palo Alto Hlth Care Syst, Palo Alto Vet Inst Res, Palo Alto, CA 94304 USA
8.Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

Wan, Hao,Yue, Jingying,Zhu, Shoujun,et al. A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues[J]. Nature Communications,2018,9.

Wan, Hao.,Yue, Jingying.,Zhu, Shoujun.,Uno, Takaaki.,Zhang, Xiaodong.,...&Dai, Hongjie.(2018).A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues.Nature Communications,9.

Wan, Hao,et al."A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues".Nature Communications 9(2018).