Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development

Qiu, Wenhui1; Shao, Haiyang2,3; Lei, Penghui2,4; Zheng, Chunmiao1; Qiu, Cunxin5; Yang, Ming2; Zheng, Yi1

2018-03

10.1016/j.chemosphere.2017.11.125

CHEMOSPHERE   影响因子和分区

0045-6535

1879-1298

Bisphenol S (BPS) and bisphenol F (BPF) have been increasingly used as alternatives to bisphenol A (BPA) owing to health concerns. The present study aims to evaluate the impact of these two BPA analogs on oxidative stress and the immune system during zebrafish embryonic and larval development. Environmentally relevant levels of BPS and BPF exposure could increase reactive oxygen species (ROS) content, nitric oxide (NO) content, nitric oxide synthase (NOS) activity, and the expression of immunity-related genes in concentration dependent manners during the early developmental stages in zebrafish. At a concentration of 100 mu g/L, BPS and BPF showed similar effects on the immune toxicity of zebrafish as that of BPA. Moreover, BPS and BPF induced both er alpha and nf-kappa b expression, and antagonists of estrogen receptor and NF-kappa B blocked the effects on immunity-related gene expression, providing evidence that the two pathways mediate the actions of BPS and BPF on fish immune response and functions. Thus we conclude that the presence of BPS and BPF in the environment, similar to BPA, may also pose risks to ecosystem and human health and cannot be widely used without limitations and precautions. (C) 2017 Elsevier Ltd. All rights reserved.

Bisphenols Oxidative stress Immune regulation Estrogen receptor Nuclear factor-kappa b Zebrafish

SCI ; EI

英语

第一 ; 通讯

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control[2017B030301012]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000423890700001

PERGAMON-ELSEVIER SCIENCE LTD

20174904489586

Bandpass filters ; Gene expression ; Health risks ; Immune system ; Nitric oxide ; Oxidative stress ; Toxicity

Bioengineering and Biology:461 ; Electric Filters:703.2 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2

ENVIRONMENT/ECOLOGY

Web of Science

1.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen Key Lab Soil & Groundwater Pollut Contro, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen 518055, Guangdong, Peoples R China
2.Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
3.Shanghai Environm Monitoring Ctr, Shanghai 200235, Peoples R China
4.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China
5.Huangshan Peoples Hosp, Dept Cardiol, Huangshan 245000, Anhui, Peoples R China

Qiu, Wenhui,Shao, Haiyang,Lei, Penghui,et al. Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development[J]. CHEMOSPHERE,2018,194:1-8.

Qiu, Wenhui.,Shao, Haiyang.,Lei, Penghui.,Zheng, Chunmiao.,Qiu, Cunxin.,...&Zheng, Yi.(2018).Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development.CHEMOSPHERE,194,1-8.

Qiu, Wenhui,et al."Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development".CHEMOSPHERE 194(2018):1-8.