Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration

Han, Lu1; Sun, Honglong1; Tang, Pengfei1; Li, Pengfei1; Xie, Chaoming1; Wang, Menghao1; Wang, Kefeng2; Weng, Jie1; Tan, Hui3; Ren, Fuzeng4; Lu, Xiong1

2018-03

10.1039/c7bm01060e

Biomaterials Science   影响因子和分区

2047-4830

2047-4849

Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have good biocompatibility and wide applications in bone engineering. In this study, a GO-functionalized Ti porous scaffold (GO/Ti scaffold) was prepared by depositing GO onto polydopamine (PDA) modified Ti scaffolds. The mussel-inspired PDA modification facilitated the interaction between GO and Ti surfaces, leading to a uniform coverage of GO on Ti scaffolds. BMP2 and vancomycin (Van) were separately encapsulated into gelatin microspheres (GeIMS). Then, drug-containing GeIMS were assembled on GO/Ti scaffolds and anchored by the functional groups of GO. The modified scaffold independently delivered multiple biomolecules with different physiochemical properties, without interfering with each other. Thus, the GO/Ti scaffold has the dual functions of inducing bone regeneration and preventing bacterial infection. in summary, this mussel-inspired GO/Ti hybrid scaffold combined the good mechanical properties of Ti scaffolds and the advantages of GO nanosheets. GO nanosheets with their unique nanostructure and functional groups, together with GeIMS on Ti scaffolds, are suitable carriers for drug delivery and provide adhesive sites for cell adhesion and create nanostructured environments for bone regeneration.

SCI ; EI

英语

其他

China Postdoctoral Science Foundation[2017M612939]

Materials Science

Materials Science, Biomaterials

WOS:000426392200008

ROYAL SOC CHEMISTRY

20181004857928

Biocompatibility ; Bone ; Cell adhesion ; Controlled drug delivery ; Graphene ; Medical applications ; Microspheres ; Molluscs ; Nanosheets ; Targeted drug delivery ; Titanium oxides

Bioengineering and Biology:461 ; Marine Science and Oceanography:471 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Solid State Physics:933

Web of Science

1.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China
2.Sichuan Univ, Natl Engn Res Ctr Biomat, Genome Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Neurosurg, Affiliated Hosp 1, Shenzhen 518035, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China

Han, Lu,Sun, Honglong,Tang, Pengfei,et al. Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration[J]. Biomaterials Science,2018,6(3):538-549.

Han, Lu.,Sun, Honglong.,Tang, Pengfei.,Li, Pengfei.,Xie, Chaoming.,...&Lu, Xiong.(2018).Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration.Biomaterials Science,6(3),538-549.

Han, Lu,et al."Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration".Biomaterials Science 6.3(2018):538-549.