| 题名 | Enantioselective Organocatalytic 1,6-Addition of Aziactones to &ITpara&IT-Quinone Methides: An Access to alpha,alpha-Disubstituted and beta,beta-Diaryl-alpha-amino acid Esters |
| 作者 | |
| 通讯作者 | Li, Wenjun; Li, Pengfei |
| 发表日期 | 2018-02-16
|
| DOI | |
| 发表期刊 | |
| ISSN | 1523-7060
|
| EISSN | 1523-7052
|
| 卷号 | 20期号:4页码:1142-1145 |
| 摘要 | This work describes the first enantioselective 1,6-additions of azlactones to para-quinone methides. In the presence of a chiral phosphoric acid, 1,6-adducts were obtained in high yields (up to 96%) with excellent diastereoselectivities and enantioselectivities (all >20:1 dia-stereoselectivity ratio (dr), up to 99% enantiomeric excess (ee)). Importantly, the method offers a facile synthetic approach, not only to enantiopure alpha,alpha-disubstituted alpha-amino acid esters, but also to unnatural enantioenriched beta,beta-diaryl-alpha-amino acid esters bearing adjacent tertiary and quaternary stereogenic centers. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 通讯
|
| 资助项目 | Special Funds for the Development of Strategic Emerging Industries in Shenzhen[VJCYJ20160429191918729]
|
| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Organic
|
| WOS记录号 | WOS:000426013600062
|
| 出版者 | |
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：91
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/28026 |
| 专题 | 理学院_化学系 |
| 作者单位 | 1.Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China |
| 通讯作者单位 | 化学系 |
| 推荐引用方式 GB/T 7714 |
Li, Wenjun,Xu, Xianhong,Liu, Yang,et al. Enantioselective Organocatalytic 1,6-Addition of Aziactones to &ITpara&IT-Quinone Methides: An Access to alpha,alpha-Disubstituted and beta,beta-Diaryl-alpha-amino acid Esters[J]. ORGANIC LETTERS,2018,20(4):1142-1145.
|
| APA |
Li, Wenjun,Xu, Xianhong,Liu, Yang,Gao, Hua,Cheng, Yuyu,&Li, Pengfei.(2018).Enantioselective Organocatalytic 1,6-Addition of Aziactones to &ITpara&IT-Quinone Methides: An Access to alpha,alpha-Disubstituted and beta,beta-Diaryl-alpha-amino acid Esters.ORGANIC LETTERS,20(4),1142-1145.
|
| MLA |
Li, Wenjun,et al."Enantioselective Organocatalytic 1,6-Addition of Aziactones to &ITpara&IT-Quinone Methides: An Access to alpha,alpha-Disubstituted and beta,beta-Diaryl-alpha-amino acid Esters".ORGANIC LETTERS 20.4(2018):1142-1145.
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
; 
修改评论