Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

Yang, Qinglai1,4,5; Hu, Zhubin2; Zhu, Shoujun3; Ma, Rui1; Ma, Huilong1; Ma, Zhuoran3; Wan, Hao1,3; Zhu, Tong6; Jiang, Zhengyan1; Liu, Weiqiang4; Jiao, Liying5; Sun, Haitao2; Liang, Yongye1; Dai, Hongjie3

2018-02-07

10.1021/jacs.7b10334

Journal of the American Chemical Society   影响因子和分区

0002-7863

Organic fluorophores have been widely used for biological imaging in the visible and the first near-infrared windows. However, their application in the second near infrared window (NIR-II, 1000-1700 nm) is still limited mainly due to low fluorescence quantum yields (QYs). Here, we explore molecular engineering on the donor unit to develop high performance NIR-II fluorophores. The fluorophores are constructed by a shielding unit-donor(s)-acceptor-donor(s)-shielding unit structure. Thiophene is introduced as the second donor connected to the shielding unit, which can increase the conjugation length and red-shift the fluorescence emission. Alkyl thiophene is employed as the first donor connected to the acceptor unit. The bulky and hydrophobic alkyl thiophene donor affords larger distortion of the conjugated backbone and fewer interactions with water molecules compared to other donor units studied before. The molecular fluorophore IR-FTAP with octyl thiophene as the first donor and thiophene as the second donor exhibits fluorescence emission peaked at 1048 nm with a QY of 5.3% in aqueous solutions, one of the highest for molecular NIR-II fluorophore reported so far. Superior temporal and spatial resolutions have been demonstrated with IR-FTAP fluorophore for NIR-II imaging of the blood vessels of a mouse hindlimb.

SCI ; EI ; IC

英语

NI论文 ; ESI高被引

第一 ; 通讯

Shanghai-International Scientific Cooperation Fund[16520721200]

Chemistry

Chemistry, Multidisciplinary

WOS:000424851500024

AMER CHEMICAL SOC

20180704804500

Blood vessels ; Fluorescence ; Infrared devices ; Molecules ; Shielding ; Solutions ; Thiophene

Biological Materials and Tissue Engineering:461.2 ; Light/Optics:741.1 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

Web of Science

1.South Univ Sci & Technol China, Shenzhen Key Lab Printed Organ Elect, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.East China Normal Univ, Sch Phys & Mat Sci, State Key Lab Precis Spect, Shanghai 200062, Peoples R China
3.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
4.Tsinghua Univ Shenzhen, Res Inst, Res Ctr Adv Mat & Biotechnol, Shenzhen 518057, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
6.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

Yang, Qinglai,Hu, Zhubin,Zhu, Shoujun,et al. Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance[J]. Journal of the American Chemical Society,2018,140(5):1715-1724.

Yang, Qinglai.,Hu, Zhubin.,Zhu, Shoujun.,Ma, Rui.,Ma, Huilong.,...&Dai, Hongjie.(2018).Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance.Journal of the American Chemical Society,140(5),1715-1724.

Yang, Qinglai,et al."Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance".Journal of the American Chemical Society 140.5(2018):1715-1724.