EGFR and Ras regulate DDX59 during lung cancer development

Yang, Lin2; Zhang, Hanyin1; Chen, Dan1; Ding, Peikun2; Yuan, Yunchang3; Zhang, Yandong1

2018-02-05

10.1016/j.gene.2017.11.029

GENE   影响因子和分区

0378-1119

1879-0038

Oncogenes EGFR and ras are frequently mutated and activated in human lung cancers. In this report, we found that both EGFR and Ras signaling can upregulate RNA helicase DDX59 in lung cancer cells. DDX59 can be induced through the mitogen activated protein kinase (MAPK) pathway after EGFR or Ras activation. Inhibitors for Ras/Raf/MAP pathway significantly decreased DDX59 expression at both protein and mRNA levels. Through immunohistochemistry, we found that DDX59 protein expression correlated with Ras and EGFR mutation status in human lung adenocarcinoma. Finally, through a xenograft nude mice model, we demonstrated that DDX59 is pivotal for EGFR mutated lung cancer cell growth in vivo. Our study identified a novel protein downstream of Ras and EGFR, which may serve as a potential therapeutic drug target for lung cancer patients.

DDX59 RNA helicase EGFR Ras Lung cancer

SCI

英语

通讯

Department of Science and Technology in Guangdong[2017A020211024]

Genetics & Heredity

Genetics & Heredity

WOS:000423892700012

ELSEVIER SCIENCE BV

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Southern Univ Sci & Technol, Dept Biol, 1088 Xueyuan Blvd, Shenzhen, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Thorac Surg, Shenzhen, Peoples R China
3.Cent S Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha, Hunan, Peoples R China

Yang, Lin,Zhang, Hanyin,Chen, Dan,et al. EGFR and Ras regulate DDX59 during lung cancer development[J]. GENE,2018,642:95-102.

Yang, Lin,Zhang, Hanyin,Chen, Dan,Ding, Peikun,Yuan, Yunchang,&Zhang, Yandong.(2018).EGFR and Ras regulate DDX59 during lung cancer development.GENE,642,95-102.

Yang, Lin,et al."EGFR and Ras regulate DDX59 during lung cancer development".GENE 642(2018):95-102.