Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages

Qiu, Wenhui1,3,4; Yang, Ming1; Liu, Shuai1; Lei, Penghui2; Hu, Lei2; Chen, Bei3; Wu, Minghong1; Wang, Ke-Jian3

2018-01-16

10.1021/acs.est.7b04226

ENVIRONMENTAL SCIENCE & TECHNOLOGY   影响因子和分区

0013-936X

1520-5851

Bisphenol S (BES), a structural analogue of bisphenol A (BPA), has been increasingly used as a common replacement of BPA due to health concerns regarding the former. However, mounting evidence suggests, that BPS has similar endocrine-disrupting effects as BPA, and likewise, its presence in the environment may :pose considerable risks to ecosystems and human health. Using fish primary macro-phageS (fpMQs), we here evaluated the immunothodulatory effects of BPS and its mechanisms, of action associated with estrogen receptors (ERs). Following BPS exposure at environmentally relevant concentrations from 0.1 to 1000 mu g/l. we observed approximate concentration-dependent increases in nitric oxide and reactive oxygen species generation and total antioxidant capacity as well as the gene expression of inflammatory cytokines in fpMQs. BPS impaired phagocytic capability but enhanced fpMQ activation levels in response to lipopolysaccharide stimulation and promoted apoptosis, indicating an impact on cell functions. At a concentration of 100 mu g/L, BPS and BPA showed comparable pro-inflammatory. potential with both up-regulating the production of free radicals and cytokine expression; however, BPS had no significant potency with regard's to inducing lipid peroxidation and apoptosis, different from BPA's effects. Moreover, BPS induced both era and er,62 expression in fpMQs, whereas BPA induced only era expression. This study demonstrates that, similarly to BPA, exposure to low doses of BPS significantly disturbs the immune response of fpMQs in vitro and first reveals overlapping but different roles of ERs in response to BPS and BPA.

SCI ; EI

英语

NI期刊

其他

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control[2017B030301012]

Engineering ; Environmental Sciences & Ecology

Engineering, Environmental ; Environmental Sciences

WOS:000423012200049

AMER CHEMICAL SOC

20180604761684

Cell death ; Endocrine disrupters ; Fish ; Free radical reactions ; Free radicals ; Health risks ; Macrophages ; Nitric oxide ; Phenols

Bioengineering and Biology:461 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2

ENVIRONMENT/ECOLOGY

Web of Science

1.Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China
3.Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361005, Fujian, Peoples R China
4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Soil & Groundwater Pollut, Sch Environm Sci & Engn, Shenzhen Key Lab Soil & Groundwater Pollut Contro, Shenzhen 518055, Guangdong, Peoples R China

Qiu, Wenhui,Yang, Ming,Liu, Shuai,et al. Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(2):831-838.

Qiu, Wenhui.,Yang, Ming.,Liu, Shuai.,Lei, Penghui.,Hu, Lei.,...&Wang, Ke-Jian.(2018).Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(2),831-838.

Qiu, Wenhui,et al."Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.2(2018):831-838.