Phosphine-mediated enantioselective [1+4]-annulation of Morita-Baylis-Hillman carbonates with 2-enoylpyridines

Wang, Tao1,2; Zhang, Pengfei1,2,3; Li, Wenjun4; Li, Pengfei1,2

2018

10.1039/c8ra09453e

RSC Advances   影响因子和分区

2046-2069

This work describes a phosphine-catalyzed asymmetric [1 + 4] annulation of Morita-Baylis-Hillman carbonates with 2-enoylpyridines for constructing the enantiomerically enriched 2,3-dihydrofuran motif. In the presence of (-)-1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene, a series of Morita-Baylis-Hillman carbonates reacted with 2-enoylpyridines smoothly to afford a wide range of optically active 2,3-dihydrofurans featuring pyridine motifs in high yields with excellent asymmetric induction.

SCI ; EI

英语

第一 ; 通讯

Shenzhen Nobel Prize Scientists Laboratory Project[C17783101]

Chemistry

Chemistry, Multidisciplinary

WOS:000453914300059

ROYAL SOC CHEMISTRY

20185106274824

Carbonates ; Phosphorus compounds

Chemical Reactions:802.2 ; Inorganic Compounds:804.2

Web of Science

1.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China
3.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150080, Heilongjiang, Peoples R China
4.Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Shandong, Peoples R China

Wang, Tao,Zhang, Pengfei,Li, Wenjun,et al. Phosphine-mediated enantioselective [1+4]-annulation of Morita-Baylis-Hillman carbonates with 2-enoylpyridines[J]. RSC Advances,2018,8(72):41620-41623.

Wang, Tao,Zhang, Pengfei,Li, Wenjun,&Li, Pengfei.(2018).Phosphine-mediated enantioselective [1+4]-annulation of Morita-Baylis-Hillman carbonates with 2-enoylpyridines.RSC Advances,8(72),41620-41623.

Wang, Tao,et al."Phosphine-mediated enantioselective [1+4]-annulation of Morita-Baylis-Hillman carbonates with 2-enoylpyridines".RSC Advances 8.72(2018):41620-41623.