Biodegradable Polymer Nanoparticles for Photodynamic Therapy by Bioluminescence Resonance Energy Transfer

Yang, Yingkun1; Hou, Weiying1; Liu, Siyang1; Sun, Kai1; Li, Minyong2; Wu, Changfeng3

2018-01

10.1021/acs.biomac.7b01469

BIOMACROMOLECULES   影响因子和分区

1525-7797

1526-4602

Conventional photodynamic therapy is severely constrained by the limited light-penetration depth in tissue. Here, we show efficient photodynamic therapy (PDT) mediated by bioluminescence resonance energy transfer (BRET) that overcomes the light-penetration limitation. The photosensitizer Rose Bengal (RB) was loaded in biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles, which were then conjugated with firefly luciferase. Spectroscopic characterizations indicated that BRET effectively activated RB to generate reactive oxygen species (ROS). In vitro studies of the cellular cytotoxicity and photodynamic effect indicated that cancer cells were effectively destroyed by BRET-PDT treatment. In vivo studies in a tumor-bearing mouse model demonstrated that tumor growth was significantly inhibited by BRET-PDT in the absence of external light irradiation. The BRET-mediated phototherapy provides a promising approach to overcome the light-penetration limitation in photodynamic treatment of deep-seated tumors.

SCI ; EI

英语

通讯

Shenzhen Science and Technology Innovation Commission[JCYJ20170307110157501]

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science

WOS:000419998600020

AMER CHEMICAL SOC

20180304648650

Biodegradable polymers ; Bioluminescence ; Energy transfer ; Nanoparticles ; Phosphorescence ; Photosensitizers ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Nanotechnology:761 ; Polymeric Materials:815.1 ; Solid State Physics:933

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
2.Shandong Univ, Sch Pharm, Dept Med Chem, Key Lab Chem Biol Nat Prod MOE, Jinan 250012, Shandong, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Yang, Yingkun,Hou, Weiying,Liu, Siyang,et al. Biodegradable Polymer Nanoparticles for Photodynamic Therapy by Bioluminescence Resonance Energy Transfer[J]. BIOMACROMOLECULES,2018,19(1):201-208.

Yang, Yingkun,Hou, Weiying,Liu, Siyang,Sun, Kai,Li, Minyong,&Wu, Changfeng.(2018).Biodegradable Polymer Nanoparticles for Photodynamic Therapy by Bioluminescence Resonance Energy Transfer.BIOMACROMOLECULES,19(1),201-208.

Yang, Yingkun,et al."Biodegradable Polymer Nanoparticles for Photodynamic Therapy by Bioluminescence Resonance Energy Transfer".BIOMACROMOLECULES 19.1(2018):201-208.