Biofilm control by interfering with c-di-GMP metabolism and signaling

Liu，Xiaobo1,2,3; Cao，Bin3,4; Yang，Liang5; Gu，Ji Dong2,6,7

2022-05-01

10.1016/j.biotechadv.2022.107915

BIOTECHNOLOGY ADVANCES   影响因子和分区

0734-9750

1873-1899

Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small nucleotide-based signaling molecule in bacteria, which functions as a second messenger mediating a wide range of bacterial processes, such as cell motility, biofilm formation, virulence expression, and cell cycle progression. C-di-GMP regulated phenotypes are triggered by a variety of determinants, such as metabolic cues and stress factors that affect c-di-GMP synthesis, the transduction and conducting of signals by specific effectors, and their actions on terminal targets. Therefore, understanding of the regulatory mechanisms of c-di-GMP would greatly benefit the control of the relevant bacterial processes, particularly for the development of anti-biofilm technologies. Here, we discuss the regulatory determinants of c-di-GMP signaling, identify the corresponding chemical inhibitors as anti-biofilm agents, and shed light on further perspectives in the metabolic regulation of c-di-GMP through chemical and biological approaches. This review will advance the development of anti-biofilm policies applied in the industries of medicine, environment and engineering.

Anti-biofilm agents Biofilm formation C-di-GMP Inhibitors Signaling

SCI ; EI

英语

其他

National Natural Science Foundation of China[32100101,92051103]

Biotechnology & Applied Microbiology

Biotechnology & Applied Microbiology

WOS:000804818700007

PERGAMON-ELSEVIER SCIENCE LTD

20220611606514

Bacteria ; Biofilms ; Cell signaling ; Metabolism ; Process control

Biomedical Engineering:461.1 ; Biomaterials (including synthetics):462.5

BIOLOGY & BIOCHEMISTRY

2-s2.0-85124157235

Scopus

1.School of Environmental and Biological Engineering,Nanjing University of Science and Technology,Nanjing,200 Xiaolingwei Street,210094,China
2.Environmental Science and Engineering Research Group,Guangdong Technion – Israel Institute of Technology,Shantou,241 Daxue Road,515063,China
3.Singapore Centre for Environmental Life Sciences Engineering,Nanyang Technological University,Singapore,60 Nanyang Drive,637551,Singapore
4.School of Civil and Environmental Engineering,Nanyang Technological University,Singapore,50 Nanyang Ave,639798,Singapore
5.School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China
6.Guangdong Provincial Key Laboratory of Materials and Technologies for Energy Conversion,Guangdong Technion – Israel Institute of Technology,Shantou,241 Daxue Road,515063,China
7.Southern Laboratory of Ocean Science and Engineering (Guangdong,Zhuhai),Zhuhai,China

Liu，Xiaobo,Cao，Bin,Yang，Liang,et al. Biofilm control by interfering with c-di-GMP metabolism and signaling[J]. BIOTECHNOLOGY ADVANCES,2022,56.

Liu，Xiaobo,Cao，Bin,Yang，Liang,&Gu，Ji Dong.(2022).Biofilm control by interfering with c-di-GMP metabolism and signaling.BIOTECHNOLOGY ADVANCES,56.

Liu，Xiaobo,et al."Biofilm control by interfering with c-di-GMP metabolism and signaling".BIOTECHNOLOGY ADVANCES 56(2022).