Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy

Chen, Haobin1,2; Zhang, Jian3; Chang, Kaiwen2,3; Men, Xiaoju1,2; Fang, Xiaofeng2; Zhou, Libo1; Li, Dongliang3; Gao, Duyang3; Yin, Shengyan1; Zhang, Xuanjun3; Yuan, Zhen3; Wu, Changfeng2

2017-11

10.1016/j.biomaterials.2017.08.007

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Semiconducting polymers with specific absorption are useful in various applications, including organic optoelectronics, optical imaging, and nanomedicine. However, the optical absorption of a semi-conducting polymer with a determined structure is hardly tunable when compared with that of inorganic semiconductors. In this work, we show that the optical absorption of polymer nanoparticles from one conjugated backbone can be effectively tuned through judicious design of the particle morphology and the persistence length of polymers. Highly absorbing near-infrared (NIR) polymers based on diketopyrrolopyrrole-dithiophene (DPP-DT) are synthesized to have different molecular weights (MWs). The DPP-DT polymer with a large molecular weight and high persistence length exhibited remarkably high optical absorption with a peak mass extinction coefficient of 81.7 L g(-1) cm(-1), which is one of the highest value among various photothermal agents reported to date. Particularly, the polymer nano particles with different sizes exhibit broadly tunable NIR absorption peaks from 630 to 811 nm. The PEGylated small polymer dots (Pdots) show good NIR light-harvesting efficiency and high non-radiative decay rates, resulting in a relatively high photothermal conversion efficiency in excess of 50%. Thus, this Pdot-based platform can serve as promising photothermal agents and photoacoustic probes for cancer theranostics. (C) 2017 Elsevier Ltd. All rights reserved.

Photothermal therapy Photoacoustic imaging Near-infrared absorption Polymer dots Contrast agents

SCI ; EI

英语

通讯

Macao government[026/2014/A1] ; Macao government[025/2015/A1] ; Macao government[052/2015/A2]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000411420000004

ELSEVIER SCI LTD

20173404061339

Efficiency ; Infrared devices ; Light absorption ; Medical nanotechnology ; Molecular weight ; Nanoparticles ; Photoacoustic effect ; Semiconducting polymers

Semiconducting Materials:712.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Organic Polymers:815.1.1 ; Production Engineering:913.1 ; Atomic and Molecular Physics:931.3 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

1.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Jilin, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Univ Macau, Fac Hlth Sci, Taipa 999078, Macao, Peoples R China

Chen, Haobin,Zhang, Jian,Chang, Kaiwen,et al. Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy[J]. BIOMATERIALS,2017,144:42-52.

Chen, Haobin.,Zhang, Jian.,Chang, Kaiwen.,Men, Xiaoju.,Fang, Xiaofeng.,...&Wu, Changfeng.(2017).Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy.BIOMATERIALS,144,42-52.

Chen, Haobin,et al."Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy".BIOMATERIALS 144(2017):42-52.