Enhanced intestinal protein fermentation in schizophrenia

Liang, Ying1; Shi, Xing2,3; Shen, Yang1; Huang, Zhuoran4; Wang, Jian2,5; Shao, Changjun2,5; Chu, Yanan2,5; Chen, Jing2,5; Yu, Jun2,5,6; Kang, Yu2,5

2022-02-09

10.1186/s12916-022-02261-z

BMC Medicine   影响因子和分区

1741-7015

1741-7015

Background Emerging findings highlighted the associations of mental illness to nutrition and dysbiosis in the intestinal microbiota, but the underlying mechanisms, especially in schizophrenia (SZ), remain unclarified. Methods We conducted a case-control study of SZ patients (case to control=100:52) by performing sequencing of the gut metagenome; measurement of fecal and plasma non-targeted metabolome; including short-, medium-, and long-chain fatty acids; and targeted metabolites, along with recorded details of daily intakes of food. Results The metagenome analysis uncovered enrichment of asaccharolytic species and reduced abundance of carbohydrate catabolism pathways and enzymes in the gut of SZ patients, but increased abundance of peptidases in contrast to their significantly reduced protein intake. Fecal metabolome analysis identified increased concentrations of many protein catabolism products, including amino acids (AAs), urea, branched short-chain fatty acids, and various nitrogenous derivates of aromatic AAs in SZ patients. Protein synthesis, represented by the abundance of AA-biosynthesis pathways and aminoacyl-tRNA transferases in metagenome, was significantly decreased. The AUCs (area under the curve) of the diagnostic random forest models based on their abundance achieved 85% and 91%, respectively. The fecal levels of AA-fermentative enzymes and products uniformly showed positive correlations with the severity of psychiatric symptoms. Conclusions Our findings revealed apparent dysbiosis in the intestinal microbiome of SZ patients, where microbial metabolism is dominated by protein fermentation and shift from carbohydrate fermentation and protein synthesis in healthy conditions. The aberrant macronutrient metabolism by gut microbes highlights the importance of nutrition care and the potential for developing microbiota-targeted therapeutics in SZ.

Schizophrenia Gut microbiota Protein fermentation Macronutrient metabolism Nutrition care Dysbiosis Metagenome Metabolome

SCI

英语

其他

National Natural Science Foundation of China[31970568] ; National Science and Technology Major Project[2018ZX10712001-018-002]

General & Internal Medicine

Medicine, General & Internal

WOS:000752934800001

BMC

2-s2.0-85124262652

Web of Science

1.Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Minist Hlth,Key Lab Mental Hlth,Inst Mental Hlth, Beijing, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518055, Peoples R China
4.Huaibei Normal Univ, Sch Life Sci, Huaibei 235000, Anhui, Peoples R China
5.China Natl Ctr Bioinformat, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China

Liang, Ying,Shi, Xing,Shen, Yang,et al. Enhanced intestinal protein fermentation in schizophrenia[J]. BMC Medicine,2022,20(1).

Liang, Ying.,Shi, Xing.,Shen, Yang.,Huang, Zhuoran.,Wang, Jian.,...&Kang, Yu.(2022).Enhanced intestinal protein fermentation in schizophrenia.BMC Medicine,20(1).

Liang, Ying,et al."Enhanced intestinal protein fermentation in schizophrenia".BMC Medicine 20.1(2022).