Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV

Hu, Jingjing1,2; Gu, Ling2; Shao, Yueming2; Zhang, Renfang2; Qi, Tangkai2; Sun, Jianjun2; Wang, Zhenyan2; Song, Wei2; Tang, Yang2; Wang, Jiangrong2; Xu, Shuibao2; Yang, Junyang2; Shen, Yinzhong2; Liu, Li2; Chen, Jun2; Lu, Hongzhou1,3

2022-02-07

10.1186/s40249-022-00942-8

INFECTIOUS DISEASES OF POVERTY   影响因子和分区

2095-5162

2049-9957

["Background: Few data are available regarding the long-term case-fatality rate (CFR) among people living with HIV (PLWH) with nontuberculous mycobacteria (NTM) disease. The aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their death.","Methods: A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1, 2012, to December 31, 2020, in Shanghai, China. We used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM (DNTM) and localized NTM disease. Univariate Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term CFR.","Results: The cohort was followed up for a median of 26 months. The total CFR was 15.7% by one year and increased to 22.6% at 5 years after the diagnosis of NTM disease. The 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM (26.7% vs 19.6% for DNTM and localized NTM disease, respectively). Older age [hazard ratio (HR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P < 0.001], comorbidity (HR = 2.05, 95% CI: 1.21-3.49, P < 0.01), DNTM (HR = 2.08, 95% CI: 1.17-3.68, P < 0.05), and HIV viral load (HR = 1.32, 95% CI: 1.12-1.55, P < 0.001) were all independent risk factors for long-term CFR. In the subgroup analysis, time to culture positivity was negatively correlated with CFR in patients with DNTM (HR = 0.90, 95% CI: 0.82-0.98, P < 0.05).","Conclusions: NTM was associated with a high long-term CFR in PLWH. Further approaches to prevent NTM disease in PLWH are urgently needed."]

HIV/AIDS Nontuberculous mycobacteria Case-fatality rate Risk factor

SCI

英语

通讯

Shanghai Commission of Science and Technology["20MC1920100","21Y11901200"] ; Shanghai key Infectious Disease Project[shslczdzk01102] ; Shanghai Municipal Health Commission[GWV-10.1-XK02] ; development fund for Shanghai talents[2020089] ; Shanghai "Rising stars of Medical Talent" Youth Development Program[2019-72]

Infectious Diseases ; Parasitology ; Tropical Medicine

Infectious Diseases ; Parasitology ; Tropical Medicine

WOS:000752330800001

BMC

Web of Science

1.Bengbu Med Coll, Sch Publ Hlth, Bengbu 233000, Anhui, Peoples R China
2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Infect Dis & Immunol, 2901 Caolang Rd, Shanghai 201508, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Shenzhen 518000, Peoples R China

Hu, Jingjing,Gu, Ling,Shao, Yueming,et al. Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV[J]. INFECTIOUS DISEASES OF POVERTY,2022,11(1).

Hu, Jingjing.,Gu, Ling.,Shao, Yueming.,Zhang, Renfang.,Qi, Tangkai.,...&Lu, Hongzhou.(2022).Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV.INFECTIOUS DISEASES OF POVERTY,11(1).

Hu, Jingjing,et al."Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV".INFECTIOUS DISEASES OF POVERTY 11.1(2022).