Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses

Wang, Chang-Zheng1,2; Han, Hai-Hao1,2; Tang, Xin-Ying3; Zhou, Dong-Ming3; Wu, Changfeng4; Chen, Guo-Rong1,2; He, Xiao-Peng1,2; Tian, He1,2

2017-08-02

10.1021/acsami.7b07485

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

The seasonal outbreak of influenza causes significant morbidity and mortality worldwide because a number of influenza virus (IV) strains have been shown to infect and circulate in humans. Development of effective means to timely monitor as well as block IVs is still a challenging task. Whereas conventional fluorescence probes rely on a fluorimetric change upon recognizing IVs, here we developed simple "Supra-dots" that are formed through the aqueous supramolecular assembly between a blue-emitting polymer dot and red-emitting sialylglycan probes for the ratiometric detection of IVs. Tuning the Forster resonance energy transfer from polymer dots to glycan probes by selective sialylglycan virus recognition enables the fluorescence ratiometric determination of IVs, whereas the presence of unselective, control viruses quenched the fluorescence of the Supra dots. Meanwhile, we show that the Supra-dots can effectively inhibit the invasion of a human-infecting IV toward a human cell line, thereby making possible a unique bifunctional, supramolecular probe for influenza theranostics.

influenza virus supramolecular polymer dot probe

SCI ; EI

英语

其他

Shanghai Rising-Star Program[16QA1401400]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000407089300012

AMER CHEMICAL SOC

20173204029774

Cell culture ; Energy transfer ; Fluorescence ; Polymers ; Probes ; Supramolecular chemistry

Biology:461.9 ; Light/Optics:741.1 ; Physical Chemistry:801.4 ; Polymeric Materials:815.1

Web of Science

1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China
3.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Vaccine Res Ctr, Shanghai 200031, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 510855, Guangdong, Peoples R China

Wang, Chang-Zheng,Han, Hai-Hao,Tang, Xin-Ying,et al. Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses[J]. ACS Applied Materials & Interfaces,2017,9(30):25164-25170.

Wang, Chang-Zheng.,Han, Hai-Hao.,Tang, Xin-Ying.,Zhou, Dong-Ming.,Wu, Changfeng.,...&Tian, He.(2017).Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses.ACS Applied Materials & Interfaces,9(30),25164-25170.

Wang, Chang-Zheng,et al."Sialylglycan-Assembled Supra-Dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses".ACS Applied Materials & Interfaces 9.30(2017):25164-25170.