pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin

Tian, Boshi1,2; Liu, Shaohua1,2; Wu, Shuyi3; Lu, Wei4; Wang, Dan1,2; Jin, Lin1,2; Hu, Bin1,2; Li, Ke1,2; Wang, Zhenling1,2; Quan, Zewei5

2017-06

10.1016/j.colsurfb.2017.03.024

COLLOIDS AND SURFACES B-BIOINTERFACES   影响因子和分区

0927-7765

1873-4367

Oral chemotherapy is the preferred route for cancer treatment because it can improve the efficacy and decrease the side effects. Unfortunately, most anticancer drugs suffered from their poor oral bioavailability. Herein, we construct a novel pH-triggered oral drug delivery system by capping of mesoporous silica SBA-15 with pH-responsive polymer poly (acrylic acid) (PAA) via a facile graft-onto strategy. The experiment results demonstrated that the PAA brushes were anchored on the pore outlets of mesoporous silica SBA-15, which can be acted as the gatekeeper to control the drug molecules transport in and out of the pore channels. The PM capped mesoporous SBA-15 (PAA/SBA-15) exhibited a high drug loading capacity (785.7 mg/g), excellent pH-sensitivity and good biocompatibility. In gastric environment (pH=2.0), the drug doxorubicin (DOX) molecules were encapsulated in the pore channels because the pore outlets were capped with collapsed PAA. In contrast, in colonic environment (pH=7.6), it exhibited a fast release because of the removal of capping. In addition, the water solubility of DOX in colonic environment was enhanced after DOX being loaded into the pores of PAA/SBA-15. This pH-triggered oral drug delivery system has promising applications for treatment of colon cancer and other colon diseases. (C) 2017 Elsevier B.V. All rights reserved.

Mesoporous silica pH-responsive Gatekeeper Targeted release Drug delivery

SCI ; EI

英语

通讯

South University of Science and Technology of China[FRG-SUSTC1501A-17]

Biophysics ; Chemistry ; Materials Science

Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials

WOS:000402348000035

ELSEVIER SCIENCE BV

20171303506612

Biochemistry ; Biocompatibility ; Carboxylic acids ; Chemotherapy ; Controlled drug delivery ; Digestive system ; Diseases ; Drug delivery ; Drug interactions ; Mesoporous materials ; Molecules ; Silica

Bioengineering and Biology:461 ; Biochemistry:801.2 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Zhoukou Normal Univ, Key Lab Rare Earth Funct Mat & Applicat, Zhoukou 466001, Peoples R China
2.Int Joint Res Lab Biomed Nanomat Henan, Zhoukou 466001, Peoples R China
3.Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Dept Prosthodont, Guangzhou 510055, Guangdong, Peoples R China
4.Hong Kong Polytech Univ, Univ Res Facil Mat Characterizat & Device Fabrica, Hong Kong, Hong Kong, Peoples R China
5.South Univ Sci & Technol China, Dept Chem, Shenzhen, Peoples R China

Tian, Boshi,Liu, Shaohua,Wu, Shuyi,et al. pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2017,154:287-296.

Tian, Boshi.,Liu, Shaohua.,Wu, Shuyi.,Lu, Wei.,Wang, Dan.,...&Quan, Zewei.(2017).pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin.COLLOIDS AND SURFACES B-BIOINTERFACES,154,287-296.

Tian, Boshi,et al."pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin".COLLOIDS AND SURFACES B-BIOINTERFACES 154(2017):287-296.