Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum

Zhai, Jingying1; Xie, Xiaojiang2; Cherubini, Thomas1; Bakker, Eric1

2017-04

10.1021/acssensors.7b00165

ACS Sensors   影响因子和分区

2379-3694

While the titrimetric assay is one of the most precise analytical techniques available, only a limited list of complexometric chelators is available, as many otherwise promising reagents are not water-soluble. Recent work demonstrated successful titrimetry with ion-exchanging polymeric nanospheres containing hydrophobic complexing agents, so-called ionophores, opening an exciting avenue in this field. However, this method was limited to ionophores of very high affinity to the analyte and exhibited a relatively limited titration capacity. To overcome these two limitations, we report here on solvent based titration reagents. This heterogeneous titration principle is based on the dissolution of all hydrophobic recognition components in a solvent such as dichloromethane (CH2Cl2) where the ionophores are shown to maintain a high affinity to the target ions. HSV (hue, saturation, value) analysis of the images captured with a digital camera provides a convenient and inexpensive way to determine the end point. This approach is combined with an automated titration setup. The titrations of the alkali metals K+, Na+, and Li+ in aqueous solution are successfully demonstrated. The potassium concentration in human serum without pretreatment was precisely and accurately determined as 4.38 mM +/- 0.10 mM (automated titration), which compares favorably with atomic emission spectroscopy (4.47 mM +/- 0.20 mM).

ionophore-based titration reagents ion exchange principle alkali metals human serum HSV analysis

SCI ; EI

英语

其他

China Scholarship Council[] ; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung[] ; Université de Genève[]

Chemistry ; Science & Technology - Other Topics

Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology

WOS:000400541500021

AMER CHEMICAL SOC

20181705049232

Alkali metals ; Atomic emission spectroscopy ; Body fluids ; Dichloromethane ; Hydrophobicity ; Ion exchange ; Ionophores ; Metal ions ; Metals ; Solutions

Biological Materials and Tissue Engineering:461.2 ; Metallurgy:531.1 ; Alkali Metals:549.1 ; Chemistry:801 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Physical Properties of Gases, Liquids and Solids:931.2

Web of Science

1.Univ Geneva, Dept Inorgan & Analyt Chem, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China

Zhai, Jingying,Xie, Xiaojiang,Cherubini, Thomas,et al. Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum[J]. ACS Sensors,2017,2(4):606-612.

Zhai, Jingying,Xie, Xiaojiang,Cherubini, Thomas,&Bakker, Eric.(2017).Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum.ACS Sensors,2(4),606-612.

Zhai, Jingying,et al."Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum".ACS Sensors 2.4(2017):606-612.