Bio-inspired immobilization of strontium substituted hydroxyapatite nanocrystals and alendronate on the surface of AZ31 magnesium alloy for osteoporotic fracture repair

Wei, Pengbo1; Wang, Bi1; Lu, Xiong2; Xin, Renlong3; Ren, Fuzeng1

2017-03-15

10.1016/j.surfcoat.2017.01.108

SURFACE & COATINGS TECHNOLOGY   影响因子和分区

0257-8972

Osteoporosis is a significant public health problem associated with increased fracture risk. Magnesium (Mg) alloys are promising biodegradable implant materials for osteoporotic bone fracture repair due to their mechanical compatibility and biological safety. However, the degradation rate of Mg alloy does not match the healing rate of the fracture and the growth rate of new bone tissues. In order to treat and prevent osteoporosis, enhance periimplant bone formation, inhibit bone resorption and slow down the degradation of Mg alloy, herein, we developed a novel bio-inspired therapeutic coating strategy by co-immobilizing strontium (Sr) substituted hydroxyapatite (Sr-HA) nanocrystals and bisphosphonate (BP) alendronate on the surface of AZ31 Mg alloy with the aid of polydopamine and carboxymethyl chitosan (CMCS). Such novel functionalized coating can not only improve the corrosion resistance of Mg alloy but also stimulate the proliferation and differentiation of osteoblast cells due to the sustained release of ALN and Sr ions from Sr-HA nanocrystals. The present coating strategy provides deep insights into clinical repair of osteoporosis-associated fractures and can potentially be extended to design of many other orthopedic devices. (C) 2017 Elsevier B.V. All rights reserved.

Strontium-substituted hydroxyapatite Alendronate Polydopamine Osteoporosis Magnesium alloy

SCI ; EI

英语

第一 ; 通讯

Special Funds for Fundamental Research of Strategic Emerging Industries of Shenzhen[JCYJ20150331101823688]

Materials Science ; Physics

Materials Science, Coatings & Films ; Physics, Applied

WOS:000398873100046

ELSEVIER SCIENCE SA

20170703347596

Biological implants ; Biological materials ; Bone ; Corrosion resistance ; Corrosion resistant alloys ; Corrosion resistant coatings ; Degradation ; Diseases ; Fracture ; Health risks ; Hydroxyapatite ; Magnesium alloys ; Metal implants ; Nanocrystals ; Repair ; Strontium

Biological Materials and Tissue Engineering:461.2 ; Health Care:461.7 ; Metals Corrosion:539.1 ; Alkaline Earth Metals:549.2 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Maintenance:913.5 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

1.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu, Sichuan, Peoples R China
3.Chongqing Univ, Coll Mat Sci & Engn, Chongqing, Peoples R China

Wei, Pengbo,Wang, Bi,Lu, Xiong,et al. Bio-inspired immobilization of strontium substituted hydroxyapatite nanocrystals and alendronate on the surface of AZ31 magnesium alloy for osteoporotic fracture repair[J]. SURFACE & COATINGS TECHNOLOGY,2017,313:381-390.

Wei, Pengbo,Wang, Bi,Lu, Xiong,Xin, Renlong,&Ren, Fuzeng.(2017).Bio-inspired immobilization of strontium substituted hydroxyapatite nanocrystals and alendronate on the surface of AZ31 magnesium alloy for osteoporotic fracture repair.SURFACE & COATINGS TECHNOLOGY,313,381-390.

Wei, Pengbo,et al."Bio-inspired immobilization of strontium substituted hydroxyapatite nanocrystals and alendronate on the surface of AZ31 magnesium alloy for osteoporotic fracture repair".SURFACE & COATINGS TECHNOLOGY 313(2017):381-390.