| 题名 | New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease |
| 作者 | |
| 通讯作者 | Wang, Li-sheng; Yao, Jun; Nie, Yu-qiang; Li, De-feng |
| 发表日期 | 2022-01-31
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| DOI | |
| 发表期刊 | |
| EISSN | 1663-9812
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| 卷号 | 13 |
| 摘要 | Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA methylation, histone markers, and non-coding RNA expression greatly contribute to the development of the entire disease. Epigenetics regulates many functions, such as maintaining the homeostasis of the intestinal epithelium and regulating the immune system of the immune cells. In the present study, we systematically summarized the latest advances in epigenetic modification of IBD and how epigenetics reveals new mechanisms of IBD. Our present review provided new insights into the pathophysiology of IBD. Moreover, exploring the patterns of DNA methylation and histone modification through epigenetics can not only be used as biomarkers of IBD but also as a new target for therapeutic intervention in IBD patients. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | Natural Science Foundation of Guangdong Province[2018A0303100024]
; Three Engineering Training Funds in Shenzhen["SYLY201718","SYJY201714","SYLY201801"]
; Technical Research and Development Project of Shenzhen["JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ20210324113802006"]
; National Natural Science Foundation of China[81800489]
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| WOS研究方向 | Pharmacology & Pharmacy
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| WOS类目 | Pharmacology & Pharmacy
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| WOS记录号 | WOS:000756058900001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：27
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/290995 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Guangzhou Digest Dis Ctr,Dept Gastroenterol & Hep, Guangzhou, Peoples R China 2.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Peoples R China 3.Shenzhen Kangning Hosp, Shenzhen, Peoples R China 4.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Shenzhen Pe, Shenzhen, Peoples R China 5.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Peoples R China 6.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Emergency, Shenzhen, Peoples R China 7.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Gastroente, Shenzhen, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Xu, Jing,Xu, Hao-ming,Yang, Mei-feng,et al. New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease[J]. FRONTIERS IN PHARMACOLOGY,2022,13.
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| APA |
Xu, Jing.,Xu, Hao-ming.,Yang, Mei-feng.,Liang, Yu-jie.,Peng, Quan-zhou.,...&Li, De-feng.(2022).New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease.FRONTIERS IN PHARMACOLOGY,13.
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| MLA |
Xu, Jing,et al."New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease".FRONTIERS IN PHARMACOLOGY 13(2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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