Shape-Anisotropic Microembolics Generated by Microfluidic Synthesis for Transarterial Embolization Treatment

Luo, Yucheng1; Ma, Yutao1; Chen, Zijian1,2; Gao, Yanan1; Zhou, Yuping1; Liu, Xiaoya1; Liu, Xuezhe1; Gao, Xu1; Li, Zhihua1; Liu, Chuang3; Leo, Hwa Liang2; Yu, Hanry4,5,6,7; Guo, Qiongyu1

2022-02-01

10.1002/adhm.202102281

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Particulate embolic agents with calibrated sizes, which employ interventional procedures to achieve endovascular embolization, have recently attracted tremendous interest in therapeutic embolotherapies for a wide plethora of diseases. However, the particulate shape effect, which may play a critical role in embolization performances, has been rarely investigated. Here, polyvinyl alcohol (PVA)-based shape-anisotropic microembolics are developed using a facile droplet-based microfluidic fabrication method via heat-accelerated PVA-glutaraldehyde crosslinking reaction at a mild temperature of 38 degrees C. Precise geometrical controls of the microembolics are achieved with a nearly capsule shape through regulating surfactant concentration and flow rate ratio between dispersed phase and continuous phase in the microfluidics. Two specific models are employed, i.e., in vitro decellularized rabbit liver embolization model and in vivo rabbit ear embolization model, to systematically evaluate the embolization behaviors of the nonspherical microembolics. Compared to microspheres of the same volume, the elongated microembolics demonstrated advantageous endovascular navigation capability, penetration depth and embolization stability due to their comparatively smaller radial diameter and their central cylindrical part providing larger contact area with distal vessels. Such nonspherical microembolics present a promising platform to apply shape anisotropy to achieve distinctive therapeutic effects for endovascular treatments.

embolization treatment endovascular navigation microfluidic techniques penetration depths shape anisotropy

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[81971764] ; Guangdong Research Fund[2019ZT08Y191] ; Key-Area Research and Development Program of Guangdong Province[2019B010941001] ; Innovation Committee of Shenzhen Municipality[JCYJ20200109141638004] ; Shenzhen Science and Technology Innovation Commission[KQTD20200820113012029] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000753472600001

WILEY

20220711647148

Crosslinking ; Microfluidics

Microfluidics:632.5.1 ; Chemical Reactions:802.2 ; Physical Properties of Gases, Liquids and Solids:931.2

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Natl Univ Singapore, Dept Biomed Engn, Engn Dr 3,Engn Block 4,04-08, Singapore 117583, Singapore
3.Southern Univ Sci & Technol, CryoEM Ctr, Shenzhen 518055, Guangdong, Peoples R China
4.Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore
5.Agcy Sci Technol & Res, Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
6.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117593, Singapore
7.Singapore MIT Alliance Res & Technol, Singapore 138602, Singapore

Luo, Yucheng,Ma, Yutao,Chen, Zijian,et al. Shape-Anisotropic Microembolics Generated by Microfluidic Synthesis for Transarterial Embolization Treatment[J]. Advanced Healthcare Materials,2022,11.

Luo, Yucheng.,Ma, Yutao.,Chen, Zijian.,Gao, Yanan.,Zhou, Yuping.,...&Guo, Qiongyu.(2022).Shape-Anisotropic Microembolics Generated by Microfluidic Synthesis for Transarterial Embolization Treatment.Advanced Healthcare Materials,11.

Luo, Yucheng,et al."Shape-Anisotropic Microembolics Generated by Microfluidic Synthesis for Transarterial Embolization Treatment".Advanced Healthcare Materials 11(2022).