The Apolipoprotein B/A1 Ratio is Associated With Metabolic Syndrome Components, Insulin Resistance, Androgen Hormones, and Liver Enzymes in Women With Polycystic Ovary Syndrome

He, Hui1; Feng, Jiaxing1; Zhang, Shike2; Wang, Yu3; Li, Jian4; Gao, Jingshu3; Cong, Jing3; Gong, Yi5; Wu, Xiaoke3,6

2022-01-05

10.3389/fendo.2021.773781

Frontiers in Endocrinology   影响因子和分区

1664-2392

AimTo evaluate the association between the apolipoprotein B/A1 ratio (ApoB/ApoA1) and metabolic and endocrine parameters in women with polycystic ovary syndrome (PCOS). MethodsThis study was a secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial (PCOSAct), and 957 subjects with available ApoB and ApoA1 measurements were included. Tests for linear trends and linear regression were used to assess the relation between the ApoB/ApoA1 ratio and metabolic and endocrine parameters. Logistic regression was used to estimate the association between the ratio and risk of metabolic syndrome (MetS) and insulin resistance (IR). The receiver operating characteristics (ROC) curve was used to determine the predictive value of the ApoB/ApoA1 ratio for MetS and IR. ResultsThe results showed that the ApoB/ApoA1 ratio was positively associated with waist circumference, systolic blood pressure, total cholesterol, triglycerides, low-density lipoprotein, fasting plasma glucose, fasting insulin, homeostatic model assessment-insulin resistance, high free testosterone, high free androgen index, alanine transferase, aspartate transferase, and higher prevalence of MetS and IR, but was negatively correlated with high-density lipoprotein and sex hormone-binding globulin after adjusting for age and body mass index. Logistic regression showed that compared with the ApoB/ApoA1 ratio in first quartile, those in the fourth quartile demonstrated a higher risk of MetS (OR: 24.48, 95%CI: 8.54-70.15, P trend <0.001) and IR (OR: 1.78, 95%CI: 1.10-2.87, P trend <0.05) after adjusting for confounding factors. ROC curve results showed that the AUC(MetS) was 0.84 (95%CI: 0.81-0.86) and had 86.8% sensitivity and 70.3% specificity with a threshold value of 0.64, and the AUC(IR) was 0.68 (95%CI: 0.64-0.71) and had 74.3% sensitivity and 58.2% specificity with a threshold value of 0.56. ConclusionsIncreased ApoB/ApoA1 ratio was associated with worse MetS components, IR, and elevated androgen hormones and liver enzymes. The ratio might be a useful tool to screen for MetS and IR in PCOS patients.

polycystic ovary syndrome metabolic syndrome insulin resistance hyperandrogenism liver enzyme apolipoprotein ratio

SCI

英语

其他

National Key R&D Program of China, Research and Development for Modernization of Chinese Medicine, Evidence-based Evaluation of the Program of Integration of Traditional Chinese and Western Medicine for High Incidence of Gynecological Diseases[2019YFC1709500] ; National Clinical Cooperation Pilot Program of TCM and Western Medicine for Major and Difficult Diseases (National Office of Traditional Chinese Medicine), Combined Traditional Chinese and Western Medicine Infertility and Assisted Reproductive Technology[[2018]3] ; Scientific Research Fund of Heilongjiang University of Chinese Medicine, Study on Acupuncture Combined with Traditional Chinese Medicine Compound to Improve the Live Birth Rate of Patients with In Vitro Fertilization and Embryo Transfer[2019BS09]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000757997800001

FRONTIERS MEDIA SA

Web of Science

1.Heilongjiang Univ Chinese Med, Harbin, Peoples R China
2.Southern Univ Sci & Technol, Heilongjiang Univ Chinese Med, Dept Rehabil Med, Shenzhen, Peoples R China
3.Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Obstet & Gynecol, Harbin, Peoples R China
4.Guizhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guiyang, Peoples R China
5.Zhejiang Univ, Beilun Dist Peoples Hosp, Affiliated Coll Med 1, Beilun Branch, Ningbo, Peoples R China
6.Heilongjiang Prov Hosp, Harbin, Peoples R China

He, Hui,Feng, Jiaxing,Zhang, Shike,et al. The Apolipoprotein B/A1 Ratio is Associated With Metabolic Syndrome Components, Insulin Resistance, Androgen Hormones, and Liver Enzymes in Women With Polycystic Ovary Syndrome[J]. Frontiers in Endocrinology,2022,12.

He, Hui.,Feng, Jiaxing.,Zhang, Shike.,Wang, Yu.,Li, Jian.,...&Wu, Xiaoke.(2022).The Apolipoprotein B/A1 Ratio is Associated With Metabolic Syndrome Components, Insulin Resistance, Androgen Hormones, and Liver Enzymes in Women With Polycystic Ovary Syndrome.Frontiers in Endocrinology,12.

He, Hui,et al."The Apolipoprotein B/A1 Ratio is Associated With Metabolic Syndrome Components, Insulin Resistance, Androgen Hormones, and Liver Enzymes in Women With Polycystic Ovary Syndrome".Frontiers in Endocrinology 12(2022).